鐐轰簡璁撳ぇ瀹跺湪瀹夊績鍌欒€冪殑鍚屾檪涔熻兘婧�(zh菙n)纰虹嵅鐭ヨ€冭│鍫卞悕鏅傞枔鐩搁棞(gu膩n)淇℃伅锛岀挵(hu谩n)鐞冪恫(w菐ng)鏍℃彁渚� 鍏嶈不闋�(y霉)绱勭煭淇℃彁閱�鍔熻兘锛岄爯(y霉)绱勫悗鏈冩彁閱掓偍2022骞翠笂鍗婂勾缈昏璩囨牸鍫卞悕鏅傞枔銆佽€冭│鏅傞枔绛夐噸瑕佷俊鎭�!绶ㄨ集鎺ㄨ枽锛�2022骞翠笂鍗婂勾缈昏璩囨牸鑰冭│涓夌礆绛嗚绶寸繏(x铆)椤屽尟绺�銆�

The syndrome, formally known as takotsubo cardiomyopathy, is characterized by weakening of the heart’s main pumping chamber and was first identified in 1990 in Japan. It looks and sounds like a heart attack and is consequently often confused for one.

蹇冪缍滃悎寰佸(xu茅)鍚嶇偤takotsubo蹇冭倢鐥�锛屾渶鏃╀簬1990骞村湪鏃ユ湰琚櫦(f膩)鐝�(xi脿n)锛屽叾鐗瑰緛鏄績鑷熺殑涓绘车鍗€(q奴)鍔熻兘娓涘急銆傜櫏鐙€鑸囧績鑷熺梾鐩镐技锛屽洜姝ょ稉(j墨ng)甯歌娣锋穯銆�

Affecting an estimated 2,500 people in the UK each year, the syndrome also carries a risk of complications similar to that of an actual heart attack. It is unclear what causes takotsubo, but sharp spikes in adrenaline caused by acute stress like bereavement, car accidents, earthquakes and even happy events such as weddings are understood to drive loss of movement in part of the heart wall, which then precipitates the acute heart failure.

鎿�(j霉)浼扮畻锛岃嫳鍦嬫瘡骞存湁2500浜烘偅涓婂績纰庣稖鍚堝緛锛岄€欑ó缍滃悎寰侀倓鍙兘寮曠櫦(f膩)鑸囧績鑷熺梾骞剁櫦(f膩)鐧ラ浼肩殑鐥呯櫏銆傜洰鍓嶅皻涓嶆竻妤氭槸浠€涔堝皫(d菐o)鑷翠簡蹇冪缍滃悎寰�锛屼絾鎿�(j霉)浜嗚В锛屽柂瑕箣鐥涖€佽粖绂�銆佸湴闇囩敋鑷冲绂瓑鍠滀簨鎬ユ€ф噳(y墨ng)婵€寮曡捣鐨勮厧涓婅吅绱犳€ュ妵椋嗗崌锛屾渻灏�(d菐o)鑷撮儴鍒嗗績澹侀亱鍕曞柂澶�锛岄€茶€岃獦鐧�(f膩)鎬ユ€у績琛�銆�

Two molecules – called microRNA-16 and microRNA-26a — that are linked to depression, anxiety and increased stress levels had previously been detected in the blood of takotsubo patients. Researchers assessed the impact of exposing cells from human hearts (taken from organs that were unsuitable for transplants) and rat hearts to the two molecules.

姝ゅ墠鍦ㄥ績纰庣稖鍚堝緛鎮ｈ€呯殑琛€娑蹭腑妾㈡脯鍒板叐绋悕鐐哄井灏忔牳绯栨牳閰�-16鍜屽井灏忔牳绯栨牳閰�-26a鐨勫垎瀛愶紝閫欏叐绋垎瀛愯垏鎶戦儊銆佺劍鎱拰澹撳姏姘村钩鍗囬珮鏈夐棞(gu膩n)銆傜爺绌朵汉鍝¤⿻浼颁簡灏囦汉椤炲績鑷�(鍙栬嚜涓嶉仼鍚堢Щ妞嶇殑鍣ㄥ畼)鍜屽ぇ榧犲績鑷熺殑绱拌優鏆撮湶浜庨€欏叐绋垎瀛愮殑褰遍熆銆�

Afterwards, both sets of heart cells were more sensitive to adrenaline, they wrote in the journal Cardiovascular Research.

浠栧€戝湪銆婂績琛€绠＄爺绌躲€嬮洔蹇楃櫦(f膩)琛ㄧ殑鏂囩珷涓ū锛岄毃鍚庣櫦(f膩)鐝�(xi脿n)锛岄€欏叐绲勫績鑷熺窗鑳炲皪鑵庝笂鑵虹礌鏇存晱鎰熴€�

In patients with takotsubo, the bottom of the heart stops beating, and the top of the heart beats more, said the lead study author, Dr Liam Couch from Imperial College London. “Basically, we found the exact same thing happens when we increase the exposure to the molecules [in an experimental setting]. It reproduced exactly what happens in takotsubo, so it made it more likely for the takotsubo to occur.”

瑭茬爺绌剁殑涓昏浣滆€�銆佸€暒甯濆湅鐞嗗伐瀛�(xu茅)闄㈢殑鍒╀簽濮�·鑰冨鍗氬＋绋�锛屽績纰庣稖鍚堝緛鎮ｈ€呯殑蹇冭嚐搴曢儴鍋滄璺冲嫊锛岄爞閮ㄨ烦鍕曟洿澶�銆�“鍩烘湰涓婏紝鎴戝€戠櫦(f膩)鐝�(xi脿n)(鍦ㄥ椹楃挵(hu谩n)澧冧腑)鐣�(d膩ng)鎴戝€戝鍔犲績鑷熷皪閫欏叐绋垎瀛愮殑鏆撮湶鏅�锛屾渻鐧�(f膩)鐢熷畬鍏ㄧ浉鍚岀殑鎯呮硜銆傚畠婧�(zh菙n)纰哄湴鍐嶇従(xi脿n)浜嗗績纰庣稖鍚堝緛鐧�(f膩)鐢熺殑鎯呮硜锛屽洜姝や娇蹇冪缍滃悎寰佺櫦(f膩)鐢熺殑鍙兘鎬ф洿澶с€�”

Overall, the findings appeared to link long-term stress and the dramatic takotsubo response to a sudden shock.

绺界殑渚嗚锛岀爺绌剁祼(ji茅)鏋滀技涔庨’绀轰簡闀锋湡鐨勫鍔涜垏鍥犳剰澶栨墦鎿婂紩鐧�(f膩)鐨勭獊鐧�(f膩)鎬у績纰庣稖鍚堝緛涔嬮枔鐨勯棞(gu膩n)鑱�(li谩n)銆�

However, the problem is that it is not possible, for now, to diagnose takotsubo in patients before it happens, making it difficult to test whether these molecules are elevated in real-life cases, Couch explained.

鐒惰€�锛岃€冨瑙ｉ噵绋憋紝鍟忛鏄�锛岀洰鍓嶉倓涓嶈兘鍦ㄥ績纰庣稖鍚堝緛鐧�(f膩)鐢熶箣鍓嶅皪鎮ｈ€呴€茶瑷烘柗锛岄€欎娇寰楀湪鐝�(xi脿n)瀵︿腑寰堥洠妾㈡脯閫欎簺鍒嗗瓙鏄惁鍗囬珮銆�

“But if we know someone’s had takotsubo, theoretically we can measure these molecules, and then predict if they’re likely to have it again, because there’s a one in five chance that they could have it again,” he said.

浠栬锛�“浣嗗鏋滄垜鍊戠煡閬撴湁浜烘偅涓婂績纰庣稖鍚堝緛锛岀悊璜栦笂鎴戝€戝彲浠ユ娓€欎簺鍒嗗瓙锛岀劧鍚庨爯(y霉)娓粬鍊戞槸鍚﹀彲鑳藉啀娆＄櫦(f膩)鐥�锛屽洜鐐轰粬鍊戞湁浜斿垎涔嬩竴鐨勫彲鑳藉啀娆＄櫦(f膩)鐥�銆�”

Joel Rose, chief executive of the charity Cardiomyopathy UK, said the study provided important insights on a less well known and poorly understood form of cardiomyopathy. “It has the potential to improve our understanding of who may be more susceptible to developing the condition and subsequent improve our ability to manage its impact,” he said.

鎱堝杽姗熸(g貌u)“鑻卞湅蹇冭倢鐥�(Cardiomyopathy UK)”棣� 甯煼(zh铆)琛屽畼绋憋紝閫欓爡鐮旂┒灏嶄竴绋鐐轰汉鐭�銆佺己涔忎簡瑙ｇ殑蹇冭倢鐥呮彁渚涗簡閲嶈瑕嬭В锛屾湁鍙兘鎻愰珮鎴戝€戝皪閫欑ó鐤剧梾鏄撹浜庡摢浜涗汉缇ょ殑瑾�(r猫n)璀�锛岄€茶€屽寮锋垜鍊戞帶鍒跺叾褰遍熆鐨勮兘鍔涖€�”

Further research is needed, said Prof Metin Avkiran, the associate medical director at the British Heart Foundation, to “determine if drugs that block these microRNAs could be the key to avoiding broken hearts”.

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