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涓€銆佹渶浣抽伕鎿囬
1銆佸柈瀹ゆā鍨嬭棩鐗╂亽閫熼潨鑴堟淮娉ㄧ郸钘�锛岄仈(d谩)绌�(w臎n)鎱�(t脿i)婵冨害75%鎵€闇€瑕佺殑婊存敞绲﹁棩鏅�(sh铆)闁撶偤
A銆�1鍊�(g猫)鍗婅“鏈�
B銆�2鍊�(g猫)鍗婅“鏈�
C銆�3鍊�(g猫)鍗婅“鏈�
D銆�4鍊�(g猫)鍗婅“鏈�
E銆�5鍊�(g猫)鍗婅“鏈�
2銆佹煇钘ョ墿鍦ㄩ珨鍏�(n猫i)鎸変竴绱�(j铆)鍕�(d貌ng)鍔涘(xu茅)娑堥櫎锛屽鏋渒=0.0346h-1锛岃┎钘ョ墿鐨勬秷闄ゅ崐琛版湡绱勭偤
A銆�3.46h
B銆�6.92h
C銆�12h
D銆�20h
E銆�24h
3銆佹煇鍠妯″瀷钘ョ墿闈滆剤婊存敞缍�(j墨ng)3鍊�(g猫)鍗婅“鏈熷悗锛屽叾琛€钘ユ績搴﹂仈(d谩)鍒扮┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︾殑
A銆�50%
B銆�75%
C銆�88%
D銆�94%
E銆�97%
4銆佺稉(j墨ng)閬�(gu貌)6.64鍊�(g猫)鍗婅“鏈熻棩鐗╃殑琛版笡閲�
A銆�50%
B銆�75%
C銆�90%
D銆�99%
E銆�100%
5銆佸柈瀹ゆā鍨嬮潨鑴堟淮娉ㄥ拰闈滆剤娉ㄥ皠鑱�(li谩n)鍚堢敤钘�锛岄鍔戦噺(璨�(f霉)鑽峰姂閲�)鐨勮▓(j矛)绠楀叕寮�
6銆佽绠″绲﹁棩妯″瀷涓�锛岄珨鍏�(n猫i)钘ョ墿璁婂寲閫熷害绛変簬
A銆佸惛鏀堕€熷害
B銆佹秷闄ら€熷害
C銆佸惛鏀堕€熷害鑸囨秷闄ら€熷害涔嬪樊
D銆佸惛鏀堕€熷害鑸囨秷闄ら€熷害涔嬪拰
E銆佷互涓婇兘涓嶅皪(du矛)
7銆佸柈瀹ゆā鍨嬭绠″绲﹁棩涓殑鍚告敹閫熺巼甯告暩(sh霉)鐨勮▓(j矛)绠楀彲閲囩敤
A銆佹畼鏁�(sh霉)娉�
B銆佸皪(du矛)鏁�(sh霉)娉�
C銆侀€熷害娉�
D銆佺当(t菕ng)瑷�(j矛)鐭╂硶
E銆佷互涓婇兘涓嶆槸
8銆佸柈瀹ゆā鍨嬭绠″绲﹁棩涓垏X0鎴愭姣旂殑鏄�
A銆乼max
B銆丆max
C銆乲a
D銆乲
E銆丗
9銆侀潪绶�(xi脿n)鎬у嫊(d貌ng)鍔涘(xu茅)鍙冩暩(sh霉)涓叐鍊�(g猫)鏈€閲嶈鐨勫父鏁�(sh霉)鏄�
A銆並锛宬
B銆並m锛孷
C銆並锛孷
D銆並锛孋l
E銆並m锛孷m
10銆佸彲瑾�(r猫n)鐐哄彈瑭﹀埗鍔戣垏鍙冩瘮鍒跺姂鐢熺墿绛夋晥鐨勭浉灏�(du矛)鐢熺墿鍒╃敤搴UC鑼冨湇鏄�
A銆�70%锝�110%
B銆�80%锝�125%
C銆�90%锝�130%
D銆�75%锝�115%
E銆�85%锝�125%
11銆佺敓鐗╁埄鐢ㄥ害鐮旂┒鏈€甯哥敤鐨勬柟娉�
A銆佽钘ユ績搴︽硶
B銆佸翱钘ユ暩(sh霉)鎿�(j霉)娉�
C銆佽棩鐞嗘晥鎳�(y墨ng)娉�
D銆佸斁娑茶棩鐗╂績搴︽硶
E銆佽喗姹佽棩鐗╂績搴︽硶
12銆佷唬琛ㄤ簡钘ョ墿鍦ㄩ珨鍏�(n猫i)婊暀鐨勮畩鐣扮▼搴︾殑鏄�
A銆侀浂闅庣煩
B銆佷竴闅庣煩
C銆佷簩闅庣煩
D銆佷笁闅庣煩
E銆佸洓闅庣煩
13銆佸悓涓€钘ョ墿鍒嗗垾鍒舵垚浠ヤ笅鍚勫姂鍨�锛孧RT鏈€澶х殑鏄�
A銆佺墖鍔�
B銆侀绮掑姂
C銆佹暎鍔�
D銆佹憾娑插姂
E銆佹敞灏勫姂
14銆佹煇涓€鍠妯″瀷钘ョ墿鐨勬秷闄ら€熷害甯告暩(sh霉)鐐�0.3465h-1锛屽垎甯冨绌嶇偤5L锛岄潨鑴堟敞灏勭郸钘�200mg锛岀稉(j墨ng)閬�(gu貌)2灏忔檪(sh铆)鍚�(宸茬煡e-0.693=0.5)楂斿収(n猫i)琛€钘ユ績搴︽槸澶氬皯
A銆�40μg/ml
B銆�30μg/ml
C銆�20μg/ml
D銆�15μg/ml
E銆�10μg/ml
15銆佹煇钘ョ墿鍠妯″瀷闈滆剤娉ㄥ皠缍�(j墨ng)4鍊�(g猫)鍗婅“鏈熷悗锛屽叾楂斿収(n猫i)钘ラ噺鐐哄師渚�(l谩i)鐨�
A銆�1/2
B銆�1/4
C銆�1/8
D銆�1/16
E銆�1/32
16銆佸翱鎺掓硠閫熷害鑸囨檪(sh铆)闁撶殑闂�(gu膩n)绯荤偤
A銆�
B銆�
C銆�
D銆�
E銆�
17銆佷笅鍒楀摢闋�(xi脿ng)绗﹀悎澶氬姂閲忛潨鑴堟敞灏勭殑钘ョ墿鍕�(d貌ng)鍔涘(xu茅)瑕�(gu墨)寰�
A銆佸钩鍧囩┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︽槸鏈€楂樺€艰垏鏈€浣庡€肩殑绠楄(sh霉)骞冲潎鍊�
B銆佸钩鍧囩┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︽槸鏈€楂樺€艰垏鏈€浣庡€肩殑骞句綍骞冲潎鍊�
C銆佸娆¢噸寰�(f霉)绲﹁棩锛岃钘ユ績搴﹀彲闅ㄧ郸钘ユ鏁�(sh霉)鐨勫鍔犺€屼笉鏂峰崌楂�
D銆侀噸寰�(f霉)绲﹁棩鏅�(sh铆)钘ョ墿鍦ㄩ珨鍏�(n猫i)鐨勮搫绌嶉噺涓嶆柗澧炲ぇ
E銆佺鍚堝柈瀹ゆā鍨嬫寜涓€绱�(j铆)閬�(gu貌)绋嬭檿缃殑钘ョ墿锛岄€g簩(x霉)澶氭闈滆剤娉ㄥ皠绲﹁棩鍚庤钘ユ績搴﹀憟鐝�(xi脿n)鍑烘湁瑕�(gu墨)寰嬬殑娉㈠嫊(d貌ng)
18銆佷笅鍒楀摢闋�(xi脿ng)绗﹀悎澶氬姂閲忛潨鑴堟敞灏勭殑钘ョ墿鍕�(d貌ng)鍔涘(xu茅)瑕�(gu墨)寰�
A銆佸钩鍧囩┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︽槸(Css)max鑸�(Css)min鐨勭畻琛�(sh霉)骞冲潎鍊�
B銆佸钩鍧囩┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︽槸(Css)max鑸�(Css)min鐨勫咕浣曞钩鍧囧€�
C銆侀仈(d谩)绌�(w臎n)鎱�(t脿i)鏅�(sh铆)鐨凙UC0-T澶т簬鍠姂閲忕郸钘ョ殑AUC0-∞
D銆佸鍔戦噺鍑芥暩(sh霉)鑸囩郸钘ュ姂閲忔湁闂�(gu膩n)
E銆佺悊鎯崇殑骞冲潎绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴︿竴鑸槸閫氶亷(gu貌)瑾�(di脿o)鏁寸郸钘ュ姂閲廥0鍙婄郸钘ユ檪(sh铆)闁撻枔闅�τ渚�(l谩i)鐛插緱鐨�
19銆佹不鐧傝棩鐗╃洠(ji膩n)娓�(c猫)鐨勮嚚搴婃剰缇╀笉鍖呮嫭
A銆佹寚灏�(d菐o)鑷ㄥ簥鍚堢悊鐢ㄨ棩
B銆佹敼璁婅棩鐗╃檪鏁�
C銆佺⒑瀹氬悎骞剁敤钘ョ殑鍘熷墖
D銆佽棩鐗╅亷(gu貌)閲忎腑姣掔殑瑷烘柗
E銆佷綔鐐洪啱(y墨)鐧傚樊閷�(cu貌)鎴栦簨鏁呯殑閼掑畾渚濇摎(j霉)
20銆侀棞(gu膩n)浜庨洐瀹ゆā鍨嬮尟(cu貌)瑾ょ殑鏁樿堪鏈�
A銆侀洐瀹ゆā鍨嬫槸灏囨(j墨)楂旂湅鎴愯棩鐗╁垎甯冮€熷害涓嶅悓鐨勫叐鍊�(g猫)鍠厓绲勬垚鐨勯珨绯�
B銆佷腑澶鏄敱琛€娑插拰琛€娴侀潪甯歌睈瀵岀殑绲勭箶銆佸櫒瀹樼祫鎴�
C銆佸懆閭婂鏄敱琛€娑蹭緵鎳�(y墨ng)涓嶈睈瀵岀殑绲勭箶銆佸櫒瀹樼祫鎴�
D銆佽棩鐗╁湪涓ぎ瀹ゅ拰鍛ㄩ倞瀹や箣闁撲笉瀛樺湪浜ゆ彌鑸囧垎閰�
E銆佽娑蹭腑鐨勮棩鐗╁悜鍛ㄩ倞瀹ゅ垎甯冩參
21銆佽棩鐗╃殑琛ㄨ鍒嗗竷瀹圭⿳瓒婂ぇ鍓囪┎钘�
A銆佽捣鏁堣秺蹇�
B銆佺祫绻旀敐鍙栬秺灏�
C銆佽捣鏁堣秺鎱�
D銆佺祫绻旀敐鍙栬秺澶�
E銆佷唬璎濊秺蹇�
22銆佽棩鐗╃殑鍗婅“鏈熶富瑕佺敤浜庤 閲忚棩鐗╃殑
A銆佸惛鏀剁殑閫熷害
B銆佹秷闄ょ殑閫熷害
C銆佸垎甯冪殑閫熷害
D銆佺郸钘ョ殑閫斿緫
E銆佽棩鐗╃殑婧惰В搴�
23銆佹渶绨�(ji菐n)鍠殑钘ュ嫊(d貌ng)瀛�(xu茅)妯″瀷鏄�
A銆佸柈瀹ゆā鍨�
B銆侀洐瀹ゆā鍨�
C銆佷笁瀹ゆā鍨�
D銆佸瀹ゆā鍨�
E銆佷互涓婇兘涓嶆槸
浜�銆侀厤浼嶉伕鎿囬
鍠妯″瀷琛€绠″绲﹁棩
<1> 銆佽钘ユ績搴﹀叕寮�
A B C D E
<2> 銆佹畼鏁�(sh霉)婵冨害鏂圭▼
A B C D E
<3> 銆佽钘ユ績搴�-鏇茬窔(xi脿n)涓嬮潰绌�
A B C D E
<4> 銆侀仈(d谩)宄版檪(sh铆)闁�
A B C D E
<5> 銆佸嘲婵冨害
A B C D E
2銆�
<1> 銆佺┅(w臎n)鎱�(t脿i)琛€钘ユ績搴�
A B C D E
<2> 銆佺暥(d膩ng)鍔戦噺杓冧綆鏅�(sh铆)锛岃钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬮潰绌�
A B C D E
<3> 銆佺暥(d膩ng)鍔戦噺杓冨ぇ鏅�(sh铆)锛岃钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬮潰绌�
A B C D E
<4> 銆佽钘ユ績搴﹁垏鏅�(sh铆)闁撶殑闂�(gu膩n)绯�
A B C D E
<5> 銆佸崐琛版湡
A B C D E
3銆丄.鑵歌倽寰挵(hu谩n)
B.鐢熺墿鍒╃敤搴�
C.鐢熺墿鍗婅“鏈�
D.琛ㄨ鍒嗗竷瀹圭⿳
E.鍠妯″瀷钘ョ墿
<1> 銆佸湪楂斿収(n猫i)鍚勭祫绻斿櫒瀹樹腑杩呴€熷垎甯冨苟杩呴€熼仈(d谩)鍒板嫊(d貌ng)鎱�(t脿i)鍒嗗竷骞宠 鐨勮棩鐗�
A B C D E
<2> 銆佽棩鐗╅毃鑶芥眮閫�(j矛n)鍏ュ皬鑵稿悗琚皬鑵搁噸鏂板惛鏀剁殑鐝�(xi脿n)璞�
A B C D E
<3> 銆佹湇鐢ㄨ棩鐗╁悗锛屼富钘ュ埌閬�(d谩)楂斿惊鐠�(hu谩n)鐨勭浉灏�(du矛)鏁�(sh霉)閲忓拰鐩稿皪(du矛)閫熷害
A B C D E
<4> 銆侀珨鍏�(n猫i)钘ラ噺X鑸囪钘ユ績搴鐨勬瘮鍊�
A B C D E
4銆丄.V
B.BE
C.AUC
D.Cl
E.F
<1> 銆佹竻闄ょ巼
A B C D E
<2> 銆佸惛鏀剁郴鏁�(sh霉)
A B C D E
<3> 銆佽〃瑙€鍒嗗竷瀹圭⿳
A B C D E
<4> 銆佺敓鐗╃瓑鏁堟€�
A B C D E
<5> 銆佽钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬮潰绌�
A B C D E
5銆丄. MRT
B. MDIT
C. MDT
D. MAT
E. MRTiv
<1> 銆佸钩鍧囨化鐣欐檪(sh铆)闁�
A B C D E
<2> 銆佸钩鍧囧穿瑙f檪(sh铆)闁�
A B C D E
<3> 銆佸钩鍧囨憾鍑烘檪(sh铆)闁�
A B C D E
<4> 銆佸钩鍧囧惛鏀舵檪(sh铆)闁�
A B C D E
<5> 銆佸钩鍧囪檿缃檪(sh铆)闁�
A B C D E
6銆丄.V
B.Cl
C.Cmax
D.AUC
E.Css
<1> 銆佽⿻(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“琛ㄨ鍒嗗竷瀹圭⿳”鍙敤鑻辨枃绺(xi臎)琛ㄧず鐐�
A B C D E
<2> 銆佽⿻(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴�”鍙敤鑻辨枃绺(xi臎)鐐�
A B C D E
<3> 銆佽⿻(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“钘�-鏅�(sh铆)鏇茬窔(xi脿n)涓嬮潰绌�”鍙敤鑻辨枃绺(xi臎)鐐�
A B C D E
<4> 銆佽⿻(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“娓呴櫎鐜�”鍙敤鑻辨枃绺(xi臎)鐐�
A B C D E
7銆丄.C0e-kt
B.0.693/k
C.C0/k
D.X0/C0
E.X0/AUC
鍠妯″瀷闈滆剤娉ㄥ皠绲﹁棩鐨勫弮鏁�(sh霉)姹傜畻
<1> 銆佹竻闄ょ巼
A B C D E
<2> 銆佸崐琛版湡
A B C D E
<3> 銆佽钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬮潰绌�
A B C D E
<4> 銆佽〃瑙€鍒嗗竷瀹圭⿳
A B C D E
<5> 銆佽钘ユ績搴�
A B C D E
E.
灏�(du矛)浜庡鍔戦噺绲﹁棩
<1> 銆佸柈瀹ゆā鍨嬮潨鑴堟敞灏勭郸钘ョ殑骞冲潎绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴�
A B C D E
<2> 銆佸柈瀹ゆā鍨嬮潨鑴堟敞灏勭郸钘ョ┅(w臎n)鎱�(t脿i)琛€钘ユ績搴�
A B C D E
<3> 銆佸柈瀹ゆā鍨嬮潨鑴堟敞灏勭郸钘ョ殑钃勭⿳绯绘暩(sh霉)
A B C D E
<4> 銆佸柈瀹ゆā鍨嬭绠″绲﹁棩鐨勮搫绌嶇郴鏁�(sh霉)
A B C D E
9銆丄. 100锝�120ml/min
B. 80锝�100ml/min
C. 50锝�80ml/min
D. 10锝�50 ml/min
E. <10 ml/min
<1> 銆佽厧鍔熻兘姝e父鐨勬垚骞寸敺鎬ц倢閰愭竻闄ょ巼
A B C D E
<2> 銆佽紩搴﹁厧鍔熻兘娓涢€€鑰呰倢閰愭竻闄ょ巼
A B C D E
<3> 銆佷腑搴﹁厧鍔熻兘娓涢€€鑰呰倢閰愭竻闄ょ巼
A B C D E
<4> 銆佸毚(y谩n)閲嶈厧鍔熻兘娓涢€€鑰呰倢閰愭竻闄ょ巼
A B C D E
10銆�
<1> 銆佸柈瀹ゆā鍨嬮潨鑴堟敞灏勭郸钘�
A B C D E
<2> 銆佸柈瀹ゆā鍨嬮潨鑴堟淮娉ㄧ郸钘�
A B C D E
<3> 銆佸柈瀹ゆā鍨嬭绠″绲﹁棩
A B C D E
<4> 銆侀洐瀹ゆā鍨嬮潨鑴堟淮娉ㄧ郸钘�
A B C D E
<5> 銆侀洐瀹ゆā鍨嬮潨鑴堟敞灏勭郸钘�
A B C D E
11銆丄.Cl=kV
B.t1/2=0.693/k
C.Css
D.V=X0/C0
E.AUC=FX0/Vk
<1> 銆佺敓鐗╁崐琛版湡鍏紡
A B C D E
<2> 銆佽〃瑙€鍒嗗竷瀹圭⿳鍏紡
A B C D E
<3> 銆佹竻闄ょ巼鍏紡
A B C D E
涓�銆佸闋�(xi脿ng)閬告搰椤�
1銆丆ss琛ㄧず
A銆佸潽婵冨害
B銆佹渶楂樿钘ユ績搴�
C銆佹渶浣庤钘ユ績搴�
D銆佺┅(w臎n)鎱�(t脿i)琛€钘ユ績搴�
E銆佸钩鍧囪钘ユ績搴�
2銆佸柈瀹ゆā鍨嬭绠″绲﹁棩鐨勮钘ユ績搴﹁垏鏅�(sh铆)闁撶殑闂�(gu膩n)绯荤偤
A銆丆=k0(1-e-kt)/Vk
3銆佽绠″绲﹁棩涓殑F鐐�
A銆佸惛鏀剁郴鏁�(sh霉)
B銆佹秷闄ょ郴鏁�(sh霉)
C銆佸惛鏀跺崰鍔戦噺鐨勫垎?j菒n)?sh霉)鍊�
D銆佹秷闄ゅ崰鍔戦噺鐨勫垎?j菒n)?sh霉)鍊�
E銆佺敓鐗╁埄鐢ㄥ害
4銆侀潪绶�(xi脿n)鎬у嫊(d貌ng)鍔涘(xu茅)涓叐鍊�(g猫)鏈€鍩烘湰鐨勫弮鏁�(sh霉)鏄�
A銆並
B銆乂
C銆丆l
D銆並m
E銆乂m
5銆佺敓鐗╁埄鐢ㄥ害鐨勭爺绌跺寘鎷�
A銆佺敓鐗╁埄鐢ㄩ€熷害
B銆佺敓鐗╁埄鐢ㄦ檪(sh铆)闁�
C銆佺敓鐗╁埄鐢ㄧ▼搴�
D銆佺敓鐗╁埄鐢ㄩ亷(gu貌)绋�
E銆佺敓鐗╁埄鐢ㄧ祼(ji茅)鏋�
6銆佷互涓嬪爆浜庣敓鐗╃瓑鏁堟€х殑甯哥敤绲�(t菕ng)瑷�(j矛)鍒嗘瀽鏂规硶鐨勬槸
A銆佹柟宸垎鏋�
B銆侀洐鍠伌(c猫)妾㈤(y脿n)
C銆�(1-2α)缃俊鍗€(q奴)闁�
D銆佽矟钁夋柉鍒嗘瀽
E銆佺当(t菕ng)瑷�(j矛)鐭╁垎鏋�
7銆佺敤绲�(t菕ng)瑷�(j矛)鐭╂硶鍙眰鍑虹殑钘ュ嫊(d貌ng)瀛�(xu茅)鍙冩暩(sh霉)鏈�
A銆乂ss
B銆乼1/2
C銆丆l
D銆乼max
E銆�α
8銆佸奖闊跨郸钘ユ柟妗堢殑鍥犵礌鏈�
A銆佽棩鐗╃殑钘ョ悊娲绘€�
B銆佺郸钘ユ檪(sh铆)闁�
C銆佽棩鍕�(d貌ng)瀛�(xu茅)鐗规€�
D銆佹偅鑰呯殑鍊�(g猫)楂斿洜绱�
E銆佺郸钘ュ姂閲�
9銆佺郸钘ユ柟妗�?j矛ng)鈧�(g猫)楂斿寲鏂规硶鍖呮嫭
A銆佹瘮渚嬫硶
B銆佷竴榛�(di菐n)娉�
C銆佸叐榛�(di菐n)娉�
D銆侀噸寰�(f霉)涓€榛�(di菐n)娉�
E銆侀噸寰�(f霉)鍏╅粸(di菐n)娉�
10銆侀棞(gu膩n)浜庨€熺巼甯告暩(sh霉)鐨勮(shu艒)娉曟纰虹殑鏄�
A銆佷竴绱�(j铆)閫熺巼閬�(gu貌)绋嬬殑閫熷害鑸囨績搴︽垚姝f瘮
B銆侀浂绱�(j铆)閫熷害閬�(gu貌)绋嬬殑閫熷害鎭掑畾
C銆侀€熺巼甯告暩(sh霉)瓒婂ぇ锛岃〃鏄庡叾楂斿収(n猫i)閬�(gu貌)绋嬮€熷害瓒婂揩
D銆侀€熺巼甯告暩(sh霉)鐨勫柈浣嶆槸鏅�(sh铆)闁撶殑鍊掓暩(sh霉)
E銆侀浂绱�(j铆)閫熺巼甯告暩(sh霉)鑸囨績搴︽湁闂�(gu膩n)绯�
绛旀閮ㄥ垎
涓€銆佹渶浣抽伕鎿囬
1銆�
銆愭纰虹瓟妗堛€� B
銆愮瓟妗堣В鏋愩€� 閬�(d谩)绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴︾殑鍒�?j菒n)?sh霉)fss=1-(1/2)n锛宯=-3.323lg(1-fss)锛宯=2→75%銆�
2銆�
銆愭纰虹瓟妗堛€� D
銆愮瓟妗堣В鏋愩€� 鏍规摎(j霉)鍏紡锛歵1/2=0.693/k瑷�(j矛)绠�锛屽叾涓璽1/2鐐鸿棩鐗╁崐琛版湡銆倀1/2=0.693/k=0.693/0.0346h-1=20h銆�
3銆�
銆愭纰虹瓟妗堛€� C
銆愮瓟妗堣В鏋愩€� 涓嶈珫浣曠ó钘ョ墿锛岄仈(d谩)绌�(w臎n)鎱�(t脿i)鐩稿悓鍒�?j菒n)?sh霉)鎵€闇€鍗婅“鏈熺殑鍊�(g猫)鏁�(sh霉)鐩稿悓锛岀稉(j墨ng)閬�(gu貌)3鍊�(g猫)鍗婅“鏈熷悗锛岃钘ユ績搴﹂仈(d谩)鍒扮┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︾殑88%銆�
4銆�
銆愭纰虹瓟妗堛€� D
銆愮瓟妗堣В鏋愩€� 鍒╃敤鍏紡锛氳“娓涢噺=1-(1/2)n鍙互瑷�(j矛)绠楀緱鍑虹瓟妗堬紝n绛変簬鍗婅“鏈熺殑鍊�(g猫)鏁�(sh霉)銆�
5銆�
銆愭纰虹瓟妗堛€� D
銆愮瓟妗堣В鏋愩€� 棣栧姂閲忕敤X0渚�(l谩i)琛ㄧず锛屾墍浠ュ湪CD涓伕鎿囷紝涓旇棩鐗╁浐瀹氬悗鏄竴鍊�(g猫)鍥哄畾鐨勫父鏁�(sh霉)锛孋涓湁璁婇噺t涓嶅皪(du矛)锛屾墍浠ユ噳(y墨ng)閬窪銆�
6銆�
銆愭纰虹瓟妗堛€� C
銆愮瓟妗堣В鏋愩€� 琛€绠″绲﹁棩妯″瀷涓�锛岄珨鍏�(n猫i)钘ョ墿璁婂寲閫熷害绛変簬鍚告敹閫熷害鑸囨秷闄ら€熷害涔嬪樊銆�
7銆�
銆愭纰虹瓟妗堛€� A
銆愮瓟妗堣В鏋愩€� 琛€钘ユ績搴︽洸绶�(xi脿n)鐢卞闋�(xi脿ng)鎸囨暩(sh霉)寮忚〃绀烘檪(sh铆)锛屽彲閲囩敤娈樻暩(sh霉)娉曟眰鍑哄悇鎸囨暩(sh霉)闋�(xi脿ng)涓殑鍙冩暩(sh霉)锛屽惛鏀堕€熺巼甯告暩(sh霉)ka鐨勮▓(j矛)绠楀嵆鍙敤娈樻暩(sh霉)娉曘€傛畼鏁�(sh霉)娉曟槸钘ュ嫊(d貌ng)瀛�(xu茅)涓妸涓€姊濇洸绶�(xi脿n)鍒嗘鍒嗚В鎴愯嫢骞叉寚鏁�(sh霉)鍑芥暩(sh霉)鐨勪竴绋父鐢ㄦ柟娉�銆�
8銆�
銆愭纰虹瓟妗堛€� B
銆愮瓟妗堣В鏋愩€� 钘ョ墿鐨則max鐢眐a銆乲姹哄畾锛岃垏鍔戦噺澶у皬鐒�(w煤)闂�(gu膩n)銆傝€孋max鑸嘪0鎴愭姣�銆�
9銆�
銆愭纰虹瓟妗堛€� E
銆愮瓟妗堣В鏋愩€� 鏈涓昏鑰冩煡闈炵窔(xi脿n)鎬у嫊(d貌ng)鍔涘(xu茅)鏂圭▼銆傞潪绶�(xi脿n)鎬у嫊(d貌ng)鍔涘(xu茅)鏂圭▼鐐猴細-dC/dt=VmC/(Km+C)
寮忎腑锛�-dC/dt鏄墿璩�(zh矛)鍦╰鏅�(sh铆)闁撶殑婵冨害涓嬮檷閫熷害锛孠m鐐虹背姘忓父鏁�(sh霉)锛孷m鐐鸿┎閬�(gu貌)绋嬬殑鐞嗚珫鏈€澶т笅闄嶉€熷害銆傚叾涓璌m鍜孷m鏄潪绶�(xi脿n)鎬у嫊(d貌ng)鍔涘(xu茅)鍙冩暩(sh霉)涓叐鍊�(g猫)鏈€閲嶈鐨勫父鏁�(sh霉)銆傛晠鏈绛旀鎳�(y墨ng)閬窫銆�
10銆�
銆愭纰虹瓟妗堛€� B
銆愮瓟妗堣В鏋愩€� 鑻ュ彈瑭﹀埗鍔戝拰鍙冩瘮鍒跺姂AUC鐨勫咕浣曞潎鍊兼瘮鐨�90%缃俊鍗€(q奴)闁撳湪80%锝�125%鑼冨湇鍏�(n猫i)锛屼笖Cmax骞句綍鍧囧€兼瘮鐨�90%缃俊鍗€(q奴)闁撳湪75%锝�133%鑼冨湇鍏�(n猫i)锛屽墖鍒ゅ畾鍙楄│鍒跺姂鑸囧弮姣斿埗鍔戠敓鐗╃瓑鏁堛€�
11銆�
銆愭纰虹瓟妗堛€� A
銆愮瓟妗堣В鏋愩€� 琛€钘ユ績搴︽硶鏄敓鐗╁埄鐢ㄥ害鐮旂┒鏈€甯哥敤鐨勬柟娉曘€�
12銆�
銆愭纰虹瓟妗堛€� C
銆愮瓟妗堣В鏋愩€� 闆堕殠鐭╀唬琛ㄨ棩鐗╃殑琛€钘ユ績搴﹂毃鏅�(sh铆)闁撶殑璁婂寲閬�(gu貌)绋嬶紝涓€闅庣煩浠h〃浜嗚棩鐗╁湪楂斿収(n猫i)鐨勬化鐣欐儏娉�锛屼簩闅庣煩鍓囦唬琛ㄤ簡钘ョ墿鍦ㄩ珨鍏�(n猫i)婊暀鐨勮畩鐣扮▼搴�銆�
13銆�
銆愭纰虹瓟妗堛€� A
銆愮瓟妗堣В鏋愩€� 鍙f湇鍥洪珨鍒跺姂鏅�(sh铆)锛屽湪鍚告敹閫�(j矛n)鍏ラ珨寰挵(hu谩n)鍓嶉渶瑕佸厛宕╄В鎴愰绮掞紝鍚庣稉(j墨ng)婧跺嚭锛屾垚鐐烘憾瑙e湪娑查珨涓殑钘ョ墿锛屽啀琚惛鏀堕€�(j矛n)鍏ラ珨寰挵(hu谩n)銆傚洜姝�锛屽浐楂斿埗鍔戣棩鐗╁湪楂斿収(n猫i)鐨勫钩鍧囨化鐣欐檪(sh铆)闁�(MRT)鎳�(y墨ng)鍖呮嫭鍥洪珨鍒跺姂鐨勫钩鍧囧穿瑙f檪(sh铆)闁�(MDIT)锛岃棩鐗╃殑骞冲潎婧跺嚭鏅�(sh铆)闁�(MDT)锛屾憾鍑鸿棩鐗╃殑骞冲潎鍚告敹鏅�(sh铆)闁�(MAT)鍜岃棩鐗╁湪楂斿収(n猫i)鐨勫钩鍧囪檿缃�(鍒嗗竷銆佷唬璎�銆佹帓娉�)鏅�(sh铆)闁�(MRTiv)銆傛墍浠ョ墖鍔戠殑MRT鏈€澶�銆�
14銆�
銆愭纰虹瓟妗堛€� C
銆愮瓟妗堣В鏋愩€� 闈滆剤娉ㄥ皠绲﹁棩锛屾敞灏勫姂閲忓嵆鐐篨锛屾湰椤孹=200mg锛孷=5L锛屽垵濮嬭钘ユ績搴﹀強闈滆剤娉ㄥ皠鐬枔鐨勮钘ユ績搴0=X/V=200mg/5L=40mg/L=40μg/ml銆侰=C0e-kt=40μg/ml×e-0.3465×2=20μg/ml銆�
15銆�
銆愭纰虹瓟妗堛€� D
銆愮瓟妗堣В鏋愩€� 姝ら杓冪啊(ji菐n)鍠�锛岀稉(j墨ng)閬�(gu貌)涓€鍊�(g猫)鍗婅“鏈熷墿浣欒棩閲忕偤1/2锛岀稉(j墨ng)閬�(gu貌)鍏╁€�(g猫)鍗婅“鏈熶箣鍚庯紝鍓╀綑钘ラ噺鐐�1/4锛屼笁鍊�(g猫)鍗婅“鏈熶箣鍚庡墿浣欒棩閲忕偤1/8銆傛墍浠ョ稉(j墨ng)閬�(gu貌)4鍊�(g猫)鍗婅“鏈熷悗鍓╀綑钘ラ噺灏辨槸1/16銆�
16銆�
銆愭纰虹瓟妗堛€� A
銆愮瓟妗堣В鏋愩€� 鍙湁A绗﹀悎閫熷害鑸囨檪(sh铆)闁撶殑闂�(gu膩n)绯汇€�
17銆�
銆愭纰虹瓟妗堛€� E
銆愮瓟妗堣В鏋愩€� 骞冲潎绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴﹀苟闈炴渶楂樺€艰垏鏈€浣庡€肩殑浠f暩(sh霉)骞冲潎鍊�锛屽畠鏄噸寰�(f霉)绲﹁棩閬�(d谩)绌�(w臎n)鎱�(t脿i)鍚�锛屽湪涓€鍊�(g猫)绲﹁棩闁撻殧鏅�(sh铆)闁撳収(n猫i)琛€钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬬殑闈㈢⿳闄や互绲﹁棩闁撻殧鏅�(sh铆)闁撶殑鍟嗗€�銆傚娆¢噸寰�(f霉)绲﹁棩锛岀郸钘ユ鏁�(sh霉)鍏呭垎澶ф檪(sh铆)锛岃钘ユ績搴︿笉鍐嶅崌楂�锛岄仈(d谩)鍒扮┅(w臎n)鎱�(t脿i)姘村钩銆傞噸寰�(f霉)绲﹁棩鏅�(sh铆)锛岀暥(d膩ng)閬�(d谩)鍒扮┅(w臎n)鎱�(t脿i)钘ョ墿楂斿収(n猫i)钃勭⿳閲忎繚鎸佷竴鍊�(g猫)瀹氬€笺€�
18銆�
銆愭纰虹瓟妗堛€� E
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19銆�
銆愭纰虹瓟妗堛€� B
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(1)鎸囧皫(d菐o)鑷ㄥ簥鍚堢悊鐢ㄨ棩銆佹彁楂樻不鐧傛按骞�銆�
(2)纰哄畾鍚堝苟鐢ㄨ棩鐨勫師鍓�锛岃嚚搴婁笂鍚堝苟鐢ㄨ棩寮曡捣钘ユ簮鎬х柧鐥呮垨?q奴)械婊ゅ宫闀忓嵏闀滆啽?b脿o)閬撲笉灏�銆傞枊(k膩i)灞曚簡TDM鐮旂┒钘ョ墿鐨勭浉浜掍綔鐢紝灏�(du矛)纰哄畾鍚堝苟鐢ㄨ棩鍘熷墖鍏锋湁閲嶈鎰忕京銆�
(3)钘ョ墿閬�(gu貌)閲忎腑姣掔殑瑷烘柗锛岄枊(k膩i)灞昑DM灏�(du矛)闃叉钘ョ墿閬�(gu貌)閲忎腑姣掑拰钘ョ墿鎬ユ€ч亷(gu貌)閲忎腑姣掔殑瑷烘柗鍏锋湁閲嶈鎰忕京銆�
(4)浣滅偤閱�(y墨)鐧傚樊閷�(cu貌)鎴栦簨鏁呯殑閼掑畾渚濇摎(j霉)鍙婅⿻(p铆ng)鍍�(ji脿)鎮h€呯敤钘ヤ緷寰炴€х殑鎵嬫銆�
20銆�
銆愭纰虹瓟妗堛€� D
銆愮瓟妗堣В鏋愩€� 闆欏妯″瀷鍋囪ō(sh猫)韬珨鐢卞叐閮ㄥ垎绲勬垚锛屽嵆钘ョ墿鍒嗗竷閫熺巼姣旇純澶х殑涓ぎ瀹よ垏鍒嗗竷杓冩參鐨勫懆閭婂銆備腑澶鍖呮嫭琛€娑插強琛€娴佷緵鎳�(y墨ng)鍏呮矝鐨勭祫绻斾腑蹇�銆佽倽銆佽厧銆佽偤銆佸収(n猫i)鍒嗘硨鑵哄強绱�(x矛)鑳炲娑�锛岃棩鐗╅€�(j矛n)鍏ラ珨寰挵(hu谩n)鍚庤兘寰堝揩鍦板垎甯冨湪鏁村€�(g猫)涓ぎ瀹わ紝琛€娑茶垏閫欎簺绲勭箶涓殑钘ョ墿婵冨害鍙繀閫熼仈(d谩)鍒板钩琛�銆傚懆閭婂浠h〃琛€娑蹭緵鎳�(y墨ng)杓冨皯鐨勭祫绻�锛屽鑲岃倝锛岀毊鑶�锛岃剛鑲祫绻旂瓑锛岃棩鐗╃殑鍒嗗竷杓冩參銆傞洐瀹ゆā鍨嬭棩鐗╃敱涓ぎ瀹ら€�(j矛n)鍏ョ郴绲�(t菕ng)锛屽苟寰炰腑澶娑堥櫎锛屽湪涓ぎ瀹よ垏鍛ㄩ倞瀹や箣闁撹棩鐗╅€�(j矛n)琛岃憲鍙€嗘€х殑杞�(zhu菐n)閬�(y霉n)銆�
21銆�
銆愭纰虹瓟妗堛€� D
銆愮瓟妗堣В鏋愩€� 寰炶嚚搴婅搴﹁€冩叜锛屽垎甯冨绌嶅ぇ鎻愮ず鍒嗗竷寤f垨鑰呯祫绻旀敐鍙栭噺澶�銆�
22銆�
銆愭纰虹瓟妗堛€� B
銆愮瓟妗堣В鏋愩€� 鐢熺墿鍗婅“鏈熻〃绀鸿棩鐗╁緸楂斿収(n猫i)娑堥櫎鐨勫揩鎱�銆�
23銆�
銆愭纰虹瓟妗堛€� A
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1銆�
銆愭纰虹瓟妗堛€� E
銆愭纰虹瓟妗堛€� D
銆愭纰虹瓟妗堛€� C
銆愭纰虹瓟妗堛€� A
銆愭纰虹瓟妗堛€� B
銆愮瓟妗堣В鏋愩€� 鏈鑰冩煡鍠妯″瀷琛€绠″绲﹁棩鐨勫叕寮忥紝娉ㄦ剰鎺屾彙銆�
2銆�
銆愭纰虹瓟妗堛€� E
銆愭纰虹瓟妗堛€� D
銆愭纰虹瓟妗堛€� C
銆愭纰虹瓟妗堛€� A
銆愭纰虹瓟妗堛€� B
銆愮瓟妗堣В鏋愩€� 姝ら鑰冨療鐨勬槸闈炵窔(xi脿n)鎬ц棩鍕�(d貌ng)瀛�(xu茅)鐨勫叕寮�锛岄€欓(l猫i)鍏紡鐨勭壒榛�(di菐n)鏄叕寮忎腑鍚湁Vm鎴朘m锛屾澶栬瑷樹綇鍗婅“鏈熴€佽〃瑙€鍒嗗竷瀹圭⿳銆佽钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬮潰绌嶇殑琛ㄧず鏂规硶銆�
3銆�
銆愭纰虹瓟妗堛€� E
銆愭纰虹瓟妗堛€� A
銆愭纰虹瓟妗堛€� B
銆愭纰虹瓟妗堛€� D
銆愮瓟妗堣В鏋愩€� 姝ら鑰冩煡鐨勬槸钘ュ嫊(d貌ng)瀛�(xu茅)鐨勪竴鑸蹇�锛屾敞鎰忓崁(q奴)鍒ユ帉鎻°€傚柈瀹ゆā鍨嬭棩鐗╁湪楂斿収(n猫i)鍚勭祫绻斿櫒瀹樹腑杩呴€熷垎甯冨苟杩呴€熼仈(d谩)鍒板嫊(d貌ng)鎱�(t脿i)鍒嗗竷骞宠 銆傝棩鐗╅毃鑶芥眮閫�(j矛n)鍏ュ皬鑵稿悗琚皬鑵搁噸鏂板惛鏀剁殑鐝�(xi脿n)璞℃槸鑵歌倽寰挵(hu谩n)銆備富钘ュ埌閬�(d谩)楂斿惊鐠�(hu谩n)鐨勭浉灏�(du矛)鏁�(sh霉)閲忓拰鐩稿皪(du矛)閫熷害鏄敓鐗╁埄鐢ㄥ害銆傞珨鍏�(n猫i)钘ラ噺X鑸囪钘ユ績搴鐨勬瘮鍊兼槸琛ㄨ鍒嗗竷瀹圭⿳銆傝棩鐗╁湪楂斿収(n猫i)琛版笡涓€鍗婃墍鐢ㄧ殑鏅�(sh铆)闁撴槸鍗婅“鏈�銆�
4銆�
銆愭纰虹瓟妗堛€� D
銆愭纰虹瓟妗堛€� E
銆愭纰虹瓟妗堛€� A
銆愭纰虹瓟妗堛€� B
銆愭纰虹瓟妗堛€� C
銆愮瓟妗堣В鏋愩€� 鏈鑰冩煡鍚勫弮鏁�(sh霉)鐨勮〃绀烘柟娉�锛屾敞鎰忔帉鎻�銆�
5銆�
銆愭纰虹瓟妗堛€� A
銆愭纰虹瓟妗堛€� B
銆愭纰虹瓟妗堛€� C
銆愭纰虹瓟妗堛€� D
銆愭纰虹瓟妗堛€� E
銆愮瓟妗堣В鏋愩€� 鏈鑰冩煡绲�(t菕ng)瑷�(j矛)鐭╁師鐞嗕腑鍚勭ó鍚嶈鐨勭府瀵�(xi臎)锛屾敞鎰忓崁(q奴)鍒ユ帉鎻�銆�
6銆�
銆愭纰虹瓟妗堛€� A
銆愮瓟妗堣В鏋愩€� 瑭�(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“琛ㄨ鍒嗗竷瀹圭⿳”鐨勮嫳鏂囩府瀵�(xi臎)鐐篤d
銆愭纰虹瓟妗堛€� E
銆愮瓟妗堣В鏋愩€� 瑭�(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴�”鐨勮嫳鏂囩府瀵�(xi臎)鐐篊ss銆�
銆愭纰虹瓟妗堛€� D
銆愮瓟妗堣В鏋愩€� 瑭�(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“钘ユ檪(sh铆)鏇茬窔(xi脿n)涓嬮潰绌�”鑻辨枃鐐篴rea under the curve锛岀啊(ji菐n)绋�(ch膿ng)AUC銆�
銆愭纰虹瓟妗堛€� B
銆愮瓟妗堣В鏋愩€� 瑭�(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“娓呴櫎鐜�”鐨勮嫳鏂囩偤 clear,绨�(ji菐n)瀵�(xi臎)鐐篊l銆�
7銆�
銆愭纰虹瓟妗堛€� E
銆愮瓟妗堣В鏋愩€� Cl= X0/AUC
銆愭纰虹瓟妗堛€� B
銆愮瓟妗堣В鏋愩€� t1/2=0.693/k
銆愭纰虹瓟妗堛€� C
銆愮瓟妗堣В鏋愩€� AUC=C0/k
銆愭纰虹瓟妗堛€� D
銆愮瓟妗堣В鏋愩€� V=X0/C0
銆愭纰虹瓟妗堛€� A
銆愮瓟妗堣В鏋愩€� C=C0e-kt
8銆�
銆愭纰虹瓟妗堛€� E
銆愭纰虹瓟妗堛€� D
銆愭纰虹瓟妗堛€� A
銆愭纰虹瓟妗堛€� B
銆愮瓟妗堣В鏋愩€� 姝ら鑰冩煡澶氬姂閲忕郸钘ョ殑鍏紡锛屾敞鎰忔帉鎻°€�
9銆�
銆愭纰虹瓟妗堛€� A
銆愭纰虹瓟妗堛€� C
銆愭纰虹瓟妗堛€� D
銆愭纰虹瓟妗堛€� E
銆愮瓟妗堣В鏋愩€� 鑲岄厫娓呴櫎鐜囨槸鍒ゆ柗鑵庡皬鐞�?y脿n)V閬�(gu貌)鍔熻兘鐨勬寚妯�(bi膩o)銆傝厧鍔熻兘姝e父鐨勬垚骞寸敺鎬ц倢閰愭竻闄ょ巼鐐�100锝�120ml/min锛岃紩搴﹁厧鍔熻兘娓涢€€鑰呯偤50锝�80ml/min锛屼腑搴﹁厧鍔熻兘娓涢€€鑰呰倢閰愭竻闄ょ巼鍙檷鑷�10锝�50 ml/min锛屽毚(y谩n)閲嶈厧鍔熻兘娓涢€€鑰�<10 ml/min銆備竴鑸棩鐗╃殑鑵庢竻闄ょ巼鑸囬珨鍏�(n猫i)鑲岄厫娓呴櫎鐜囨垚姝f瘮銆�
10銆�
銆愭纰虹瓟妗堛€� E
銆愭纰虹瓟妗堛€� D
銆愭纰虹瓟妗堛€� C
銆愭纰虹瓟妗堛€� B
銆愭纰虹瓟妗堛€� A
銆愮瓟妗堣В鏋愩€� 鏈鑰冩煡鐨勬槸鍚勫€�(g猫)妯″瀷涓嬬殑琛€钘ユ績搴﹀叕寮�锛屾敞鎰忓崁(q奴)鍒�銆�
11銆�
銆愭纰虹瓟妗堛€� B
銆愭纰虹瓟妗堛€� D
銆愭纰虹瓟妗堛€� A
銆愮瓟妗堣В鏋愩€� 灏�(du矛)浜庡叕寮忛鐩鍏堣浣忚〃绀烘柟娉�锛屽崐琛版湡鐢╰1/2琛ㄧず锛岃〃瑙€鍒嗗竷瀹圭⿳鐢╒琛ㄧず锛屾竻闄ょ巼鐢–l琛ㄧず銆�
涓夈€佸闋�(xi脿ng)閬告搰椤�
1銆�
銆愭纰虹瓟妗堛€� AD
銆愮瓟妗堣В鏋愩€� 闈滆剤婊存敞闁�(k膩i)濮嬬殑涓€娈垫檪(sh铆)闁撳収(n猫i)锛岃钘ユ績搴﹂€愭几涓婂崌锛岀劧鍚庤定杩戜簬鎭掑畾姘村钩锛屾鏅�(sh铆)鐨勮钘ユ績搴﹀€肩ū(ch膿ng)鐐虹┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︽垨鍧績搴�锛岀敤Css琛ㄧず銆�
2銆�
銆愭纰虹瓟妗堛€� CDE
銆愮瓟妗堣В鏋愩€� E閬搁爡(xi脿ng)鏄柈瀹ゆā鍨嬭绠″绲﹁棩鐨勫師濮嬪叕寮�锛岀暥(d膩ng)t鍏呭垎澶ф檪(sh铆)鍙啊(ji菐n)鍖栫偤鍏紡CD銆�
3銆�
銆愭纰虹瓟妗堛€� ACE
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