2020鍩�(zh铆)妤�(y猫)钘ュ斧妯℃摤瑭﹂锛氥€婅棩瀛�(xu茅)灏�(zhu膩n)妤�(y猫)鐭ヨ瓨(sh铆)涓€銆嬬涔濈珷闋�(y霉)缈�(x铆)椤�

鐩搁棞(gu膩n)鎺ㄨ枽锛�2020鍩�(zh铆)妤�(y猫)钘ュ斧妯℃摤瑭﹂锛氥€婅棩瀛�(xu茅)灏�(zhu膩n)妤�(y猫)鐭ヨ瓨(sh铆)涓€銆嬮爯(y霉)缈�(x铆)椤屽悇绔犲尟绺�

2020鍩�(zh铆)妤�(y猫)钘ュ斧妯℃摤瑭﹂锛氥€婅棩瀛�(xu茅)灏�(zhu膩n)妤�(y猫)鐭ヨ瓨(sh铆)涓€銆嬬涔濈珷

钘ョ墿鐨勯珨鍏�(n猫i)鍕�(d貌ng)鍔涘(xu茅)閬�(gu貌)绋�

锛堥粸(di菐n)鎿婁笅杓�>>鍏朵粬绉戠洰銆佺珷绡€(ji茅)2020骞村煼(zh铆)妤�(y猫)钘ュ斧妯℃摤瑭﹂锛�

娉ㄦ剰锛�鐢变簬鎴嚦2鏈�17鏃ョ櫦(f膩)绋挎棩锛屽畼鏂瑰皻鏈櫦(f膩)甯�2020骞村煼(zh铆)妤�(y猫)钘ュ斧鑰冭│澶х侗鍙婅€冭│鏁欐潗锛屼笅闈㈡槸灏忕法鍙冭€�2019骞村煼(zh铆)妤�(y猫)钘ュ斧鑰冭│澶х侗鑸囪€冭│鏁欐潗鐐哄ぇ瀹舵暣鐞嗙殑妯℃摤瑭﹂銆�

灏忕法闋�(y霉)娓�(c猫)2020骞村煼(zh铆)妤�(y猫)钘ュ斧鑰冭│澶х侗鏈�(hu矛)鏈夎純澶ц畩鍖栵紝2020鍩�(zh铆)妤�(y猫)钘ュ斧銆婅棩瀛�(xu茅)灏�(zhu膩n)妤�(y猫)鐭ヨ瓨(sh铆)涓€銆嬭€冭│鏁欐潗鍙兘涔熸渻(hu矛)鍥犳鑰屾湁璁婂寲銆備絾鏄檪(sh铆)闁撲笉绛変汉锛岄洊鐒舵柊鐗堣€冭│澶х侗鍙婃暀鏉愬皻鏈櫦(f膩)甯�锛岄倓鏄珛(q菒ng)澶у鍏堟牴鎿�(j霉)2019骞寸増鐨勮硣鏂欐彁鍓嶅京(f霉)缈�(x铆)锛屼笉鐒剁暀绲﹀ぇ瀹剁殑寰�(f霉)缈�(x铆)鏅�(sh铆)闁撳彲鑳芥渻(hu矛)閬�(gu貌)鐭�銆�

涓€銆佹渶浣抽伕鎿囬

1銆佸柈瀹ゆā鍨嬭棩鐗╂亽閫熼潨鑴堟淮娉ㄧ郸钘�锛岄仈(d谩)绌�(w臎n)鎱�(t脿i)婵冨害75%鎵€闇€瑕佺殑婊存敞绲﹁棩鏅�(sh铆)闁撶偤

A銆�1鍊�(g猫)鍗婅“鏈�

B銆�2鍊�(g猫)鍗婅“鏈�

C銆�3鍊�(g猫)鍗婅“鏈�

D銆�4鍊�(g猫)鍗婅“鏈�

E銆�5鍊�(g猫)鍗婅“鏈�

2銆佹煇钘ョ墿鍦ㄩ珨鍏�(n猫i)鎸変竴绱�(j铆)鍕�(d貌ng)鍔涘(xu茅)娑堥櫎锛屽鏋渒=0.0346h-1锛岃┎钘ョ墿鐨勬秷闄ゅ崐琛版湡绱勭偤

A銆�3.46h

B銆�6.92h

C銆�12h

D銆�20h

E銆�24h

3銆佹煇鍠妯″瀷钘ョ墿闈滆剤婊存敞缍�(j墨ng)3鍊�(g猫)鍗婅“鏈熷悗锛屽叾琛€钘ユ績搴﹂仈(d谩)鍒扮┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︾殑

A銆�50%

B銆�75%

C銆�88%

D銆�94%

E銆�97%

4銆佺稉(j墨ng)閬�(gu貌)6.64鍊�(g猫)鍗婅“鏈熻棩鐗╃殑琛版笡閲�

A銆�50%

B銆�75%

C銆�90%

D銆�99%

E銆�100%

5銆佸柈瀹ゆā鍨嬮潨鑴堟淮娉ㄥ拰闈滆剤娉ㄥ皠鑱�(li谩n)鍚堢敤钘�锛岄鍔戦噺(璨�(f霉)鑽峰姂閲�)鐨勮▓(j矛)绠楀叕寮�

6銆佽绠″绲﹁棩妯″瀷涓�锛岄珨鍏�(n猫i)钘ョ墿璁婂寲閫熷害绛変簬

A銆佸惛鏀堕€熷害

B銆佹秷闄ら€熷害

C銆佸惛鏀堕€熷害鑸囨秷闄ら€熷害涔嬪樊

D銆佸惛鏀堕€熷害鑸囨秷闄ら€熷害涔嬪拰

E銆佷互涓婇兘涓嶅皪(du矛)

7銆佸柈瀹ゆā鍨嬭绠″绲﹁棩涓殑鍚告敹閫熺巼甯告暩(sh霉)鐨勮▓(j矛)绠楀彲閲囩敤

A銆佹畼鏁�(sh霉)娉�

B銆佸皪(du矛)鏁�(sh霉)娉�

C銆侀€熷害娉�

D銆佺当(t菕ng)瑷�(j矛)鐭╂硶

E銆佷互涓婇兘涓嶆槸

8銆佸柈瀹ゆā鍨嬭绠″绲﹁棩涓垏X0鎴愭姣旂殑鏄�

A銆乼max

B銆丆max

C銆乲a

D銆乲

E銆丗

9銆侀潪绶�(xi脿n)鎬у嫊(d貌ng)鍔涘(xu茅)鍙冩暩(sh霉)涓叐鍊�(g猫)鏈€閲嶈鐨勫父鏁�(sh霉)鏄�

A銆並锛宬

B銆並m锛孷

C銆並锛孷

D銆並锛孋l

E銆並m锛孷m

10銆佸彲瑾�(r猫n)鐐哄彈瑭﹀埗鍔戣垏鍙冩瘮鍒跺姂鐢熺墿绛夋晥鐨勭浉灏�(du矛)鐢熺墿鍒╃敤搴UC鑼冨湇鏄�

A銆�70%锝�110%

B銆�80%锝�125%

C銆�90%锝�130%

D銆�75%锝�115%

E銆�85%锝�125%

11銆佺敓鐗╁埄鐢ㄥ害鐮旂┒鏈€甯哥敤鐨勬柟娉�

A銆佽钘ユ績搴︽硶

B銆佸翱钘ユ暩(sh霉)鎿�(j霉)娉�

C銆佽棩鐞嗘晥鎳�(y墨ng)娉�

D銆佸斁娑茶棩鐗╂績搴︽硶

E銆佽喗姹佽棩鐗╂績搴︽硶

12銆佷唬琛ㄤ簡钘ョ墿鍦ㄩ珨鍏�(n猫i)婊暀鐨勮畩鐣扮▼搴︾殑鏄�

A銆侀浂闅庣煩

B銆佷竴闅庣煩

C銆佷簩闅庣煩

D銆佷笁闅庣煩

E銆佸洓闅庣煩

13銆佸悓涓€钘ョ墿鍒嗗垾鍒舵垚浠ヤ笅鍚勫姂鍨�锛孧RT鏈€澶х殑鏄�

A銆佺墖鍔�

B銆侀绮掑姂

C銆佹暎鍔�

D銆佹憾娑插姂

E銆佹敞灏勫姂

14銆佹煇涓€鍠妯″瀷钘ョ墿鐨勬秷闄ら€熷害甯告暩(sh霉)鐐�0.3465h-1锛屽垎甯冨绌嶇偤5L锛岄潨鑴堟敞灏勭郸钘�200mg锛岀稉(j墨ng)閬�(gu貌)2灏忔檪(sh铆)鍚�(宸茬煡e-0.693=0.5)楂斿収(n猫i)琛€钘ユ績搴︽槸澶氬皯

A銆�40μg/ml

B銆�30μg/ml

C銆�20μg/ml

D銆�15μg/ml

E銆�10μg/ml

15銆佹煇钘ョ墿鍠妯″瀷闈滆剤娉ㄥ皠缍�(j墨ng)4鍊�(g猫)鍗婅“鏈熷悗锛屽叾楂斿収(n猫i)钘ラ噺鐐哄師渚�(l谩i)鐨�

A銆�1/2

B銆�1/4

C銆�1/8

D銆�1/16

E銆�1/32

16銆佸翱鎺掓硠閫熷害鑸囨檪(sh铆)闁撶殑闂�(gu膩n)绯荤偤

A銆�

B銆�

C銆�

D銆�

E銆�

17銆佷笅鍒楀摢闋�(xi脿ng)绗﹀悎澶氬姂閲忛潨鑴堟敞灏勭殑钘ョ墿鍕�(d貌ng)鍔涘(xu茅)瑕�(gu墨)寰�

A銆佸钩鍧囩┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︽槸鏈€楂樺€艰垏鏈€浣庡€肩殑绠楄(sh霉)骞冲潎鍊�

B銆佸钩鍧囩┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︽槸鏈€楂樺€艰垏鏈€浣庡€肩殑骞句綍骞冲潎鍊�

C銆佸娆￠噸寰�(f霉)绲﹁棩锛岃钘ユ績搴﹀彲闅ㄧ郸钘ユ鏁�(sh霉)鐨勫鍔犺€屼笉鏂峰崌楂�

D銆侀噸寰�(f霉)绲﹁棩鏅�(sh铆)钘ョ墿鍦ㄩ珨鍏�(n猫i)鐨勮搫绌嶉噺涓嶆柗澧炲ぇ

E銆佺鍚堝柈瀹ゆā鍨嬫寜涓€绱�(j铆)閬�(gu貌)绋嬭檿缃殑钘ョ墿锛岄€ｇ簩(x霉)澶氭闈滆剤娉ㄥ皠绲﹁棩鍚庤钘ユ績搴﹀憟鐝�(xi脿n)鍑烘湁瑕�(gu墨)寰嬬殑娉㈠嫊(d貌ng)

18銆佷笅鍒楀摢闋�(xi脿ng)绗﹀悎澶氬姂閲忛潨鑴堟敞灏勭殑钘ョ墿鍕�(d貌ng)鍔涘(xu茅)瑕�(gu墨)寰�

A銆佸钩鍧囩┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︽槸(Css)max鑸�(Css)min鐨勭畻琛�(sh霉)骞冲潎鍊�

B銆佸钩鍧囩┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︽槸(Css)max鑸�(Css)min鐨勫咕浣曞钩鍧囧€�

C銆侀仈(d谩)绌�(w臎n)鎱�(t脿i)鏅�(sh铆)鐨凙UC0-T澶т簬鍠姂閲忕郸钘ョ殑AUC0-∞

D銆佸鍔戦噺鍑芥暩(sh霉)鑸囩郸钘ュ姂閲忔湁闂�(gu膩n)

E銆佺悊鎯崇殑骞冲潎绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴︿竴鑸槸閫氶亷(gu貌)瑾�(di脿o)鏁寸郸钘ュ姂閲廥0鍙婄郸钘ユ檪(sh铆)闁撻枔闅�τ渚�(l谩i)鐛插緱鐨�

19銆佹不鐧傝棩鐗╃洠(ji膩n)娓�(c猫)鐨勮嚚搴婃剰缇╀笉鍖呮嫭

A銆佹寚灏�(d菐o)鑷ㄥ簥鍚堢悊鐢ㄨ棩

B銆佹敼璁婅棩鐗╃檪鏁�

C銆佺⒑瀹氬悎骞剁敤钘ョ殑鍘熷墖

D銆佽棩鐗╅亷(gu貌)閲忎腑姣掔殑瑷烘柗

E銆佷綔鐐洪啱(y墨)鐧傚樊閷�(cu貌)鎴栦簨鏁呯殑閼掑畾渚濇摎(j霉)

20銆侀棞(gu膩n)浜庨洐瀹ゆā鍨嬮尟(cu貌)瑾ょ殑鏁樿堪鏈�

A銆侀洐瀹ゆā鍨嬫槸灏囨(j墨)楂旂湅鎴愯棩鐗╁垎甯冮€熷害涓嶅悓鐨勫叐鍊�(g猫)鍠厓绲勬垚鐨勯珨绯�

B銆佷腑澶鏄敱琛€娑插拰琛€娴侀潪甯歌睈瀵岀殑绲勭箶銆佸櫒瀹樼祫鎴�

C銆佸懆閭婂鏄敱琛€娑蹭緵鎳�(y墨ng)涓嶈睈瀵岀殑绲勭箶銆佸櫒瀹樼祫鎴�

D銆佽棩鐗╁湪涓ぎ瀹ゅ拰鍛ㄩ倞瀹や箣闁撲笉瀛樺湪浜ゆ彌鑸囧垎閰�

E銆佽娑蹭腑鐨勮棩鐗╁悜鍛ㄩ倞瀹ゅ垎甯冩參

21銆佽棩鐗╃殑琛ㄨ鍒嗗竷瀹圭⿳瓒婂ぇ鍓囪┎钘�

A銆佽捣鏁堣秺蹇�

B銆佺祫绻旀敐鍙栬秺灏�

C銆佽捣鏁堣秺鎱�

D銆佺祫绻旀敐鍙栬秺澶�

E銆佷唬璎濊秺蹇�

22銆佽棩鐗╃殑鍗婅“鏈熶富瑕佺敤浜庤　閲忚棩鐗╃殑

A銆佸惛鏀剁殑閫熷害

B銆佹秷闄ょ殑閫熷害

C銆佸垎甯冪殑閫熷害

D銆佺郸钘ョ殑閫斿緫

E銆佽棩鐗╃殑婧惰В搴�

23銆佹渶绨�(ji菐n)鍠殑钘ュ嫊(d貌ng)瀛�(xu茅)妯″瀷鏄�

A銆佸柈瀹ゆā鍨�

B銆侀洐瀹ゆā鍨�

C銆佷笁瀹ゆā鍨�

D銆佸瀹ゆā鍨�

E銆佷互涓婇兘涓嶆槸

浜�銆侀厤浼嶉伕鎿囬

鍠妯″瀷琛€绠″绲﹁棩

<1> 銆佽钘ユ績搴﹀叕寮�

A B C D E

<2> 銆佹畼鏁�(sh霉)婵冨害鏂圭▼

A B C D E

<3> 銆佽钘ユ績搴�-鏇茬窔(xi脿n)涓嬮潰绌�

A B C D E

<4> 銆侀仈(d谩)宄版檪(sh铆)闁�

A B C D E

<5> 銆佸嘲婵冨害

A B C D E

2銆�

<1> 銆佺┅(w臎n)鎱�(t脿i)琛€钘ユ績搴�

A B C D E

<2> 銆佺暥(d膩ng)鍔戦噺杓冧綆鏅�(sh铆)锛岃钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬮潰绌�

A B C D E

<3> 銆佺暥(d膩ng)鍔戦噺杓冨ぇ鏅�(sh铆)锛岃钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬮潰绌�

A B C D E

<4> 銆佽钘ユ績搴﹁垏鏅�(sh铆)闁撶殑闂�(gu膩n)绯�

A B C D E

<5> 銆佸崐琛版湡

A B C D E

3銆丄.鑵歌倽寰挵(hu谩n)

B.鐢熺墿鍒╃敤搴�

C.鐢熺墿鍗婅“鏈�

D.琛ㄨ鍒嗗竷瀹圭⿳

E.鍠妯″瀷钘ョ墿

<1> 銆佸湪楂斿収(n猫i)鍚勭祫绻斿櫒瀹樹腑杩呴€熷垎甯冨苟杩呴€熼仈(d谩)鍒板嫊(d貌ng)鎱�(t脿i)鍒嗗竷骞宠　鐨勮棩鐗�

A B C D E

<2> 銆佽棩鐗╅毃鑶芥眮閫�(j矛n)鍏ュ皬鑵稿悗琚皬鑵搁噸鏂板惛鏀剁殑鐝�(xi脿n)璞�

A B C D E

<3> 銆佹湇鐢ㄨ棩鐗╁悗锛屼富钘ュ埌閬�(d谩)楂斿惊鐠�(hu谩n)鐨勭浉灏�(du矛)鏁�(sh霉)閲忓拰鐩稿皪(du矛)閫熷害

A B C D E

<4> 銆侀珨鍏�(n猫i)钘ラ噺X鑸囪钘ユ績搴鐨勬瘮鍊�

A B C D E

4銆丄.V

B.BE

C.AUC

D.Cl

E.F

<1> 銆佹竻闄ょ巼

A B C D E

<2> 銆佸惛鏀剁郴鏁�(sh霉)

A B C D E

<3> 銆佽〃瑙€鍒嗗竷瀹圭⿳

A B C D E

<4> 銆佺敓鐗╃瓑鏁堟€�

A B C D E

<5> 銆佽钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬮潰绌�

A B C D E

5銆丄. MRT

B. MDIT

C. MDT

D. MAT

E. MRTiv

<1> 銆佸钩鍧囨化鐣欐檪(sh铆)闁�

A B C D E

<2> 銆佸钩鍧囧穿瑙ｆ檪(sh铆)闁�

A B C D E

<3> 銆佸钩鍧囨憾鍑烘檪(sh铆)闁�

A B C D E

<4> 銆佸钩鍧囧惛鏀舵檪(sh铆)闁�

A B C D E

<5> 銆佸钩鍧囪檿缃檪(sh铆)闁�

A B C D E

6銆丄.V

B.Cl

C.Cmax

D.AUC

E.Css

<1> 銆佽⿻(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“琛ㄨ鍒嗗竷瀹圭⿳”鍙敤鑻辨枃绺(xi臎)琛ㄧず鐐�

A B C D E

<2> 銆佽⿻(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴�”鍙敤鑻辨枃绺(xi臎)鐐�

A B C D E

<3> 銆佽⿻(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“钘�-鏅�(sh铆)鏇茬窔(xi脿n)涓嬮潰绌�”鍙敤鑻辨枃绺(xi臎)鐐�

A B C D E

<4> 銆佽⿻(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“娓呴櫎鐜�”鍙敤鑻辨枃绺(xi臎)鐐�

A B C D E

7銆丄.C0e-kt

B.0.693/k

C.C0/k

D.X0/C0

E.X0/AUC

鍠妯″瀷闈滆剤娉ㄥ皠绲﹁棩鐨勫弮鏁�(sh霉)姹傜畻

<1> 銆佹竻闄ょ巼

A B C D E

<2> 銆佸崐琛版湡

A B C D E

<3> 銆佽钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬮潰绌�

A B C D E

<4> 銆佽〃瑙€鍒嗗竷瀹圭⿳

A B C D E

<5> 銆佽钘ユ績搴�

A B C D E

E.

灏�(du矛)浜庡鍔戦噺绲﹁棩

<1> 銆佸柈瀹ゆā鍨嬮潨鑴堟敞灏勭郸钘ョ殑骞冲潎绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴�

A B C D E

<2> 銆佸柈瀹ゆā鍨嬮潨鑴堟敞灏勭郸钘ョ┅(w臎n)鎱�(t脿i)琛€钘ユ績搴�

A B C D E

<3> 銆佸柈瀹ゆā鍨嬮潨鑴堟敞灏勭郸钘ョ殑钃勭⿳绯绘暩(sh霉)

A B C D E

<4> 銆佸柈瀹ゆā鍨嬭绠″绲﹁棩鐨勮搫绌嶇郴鏁�(sh霉)

A B C D E

9銆丄. 100锝�120ml/min

B. 80锝�100ml/min

C. 50锝�80ml/min

D. 10锝�50 ml/min

E. <10 ml/min

<1> 銆佽厧鍔熻兘姝ｅ父鐨勬垚骞寸敺鎬ц倢閰愭竻闄ょ巼

A B C D E

<2> 銆佽紩搴﹁厧鍔熻兘娓涢€€鑰呰倢閰愭竻闄ょ巼

A B C D E

<3> 銆佷腑搴﹁厧鍔熻兘娓涢€€鑰呰倢閰愭竻闄ょ巼

A B C D E

<4> 銆佸毚(y谩n)閲嶈厧鍔熻兘娓涢€€鑰呰倢閰愭竻闄ょ巼

A B C D E

10銆�

<1> 銆佸柈瀹ゆā鍨嬮潨鑴堟敞灏勭郸钘�

A B C D E

<2> 銆佸柈瀹ゆā鍨嬮潨鑴堟淮娉ㄧ郸钘�

A B C D E

<3> 銆佸柈瀹ゆā鍨嬭绠″绲﹁棩

A B C D E

<4> 銆侀洐瀹ゆā鍨嬮潨鑴堟淮娉ㄧ郸钘�

A B C D E

<5> 銆侀洐瀹ゆā鍨嬮潨鑴堟敞灏勭郸钘�

A B C D E

11銆丄.Cl=kV

B.t1/2=0.693/k

C.Css

D.V=X0/C0

E.AUC=FX0/Vk

<1> 銆佺敓鐗╁崐琛版湡鍏紡

A B C D E

<2> 銆佽〃瑙€鍒嗗竷瀹圭⿳鍏紡

A B C D E

<3> 銆佹竻闄ょ巼鍏紡

A B C D E

涓�銆佸闋�(xi脿ng)閬告搰椤�

1銆丆ss琛ㄧず

A銆佸潽婵冨害

B銆佹渶楂樿钘ユ績搴�

C銆佹渶浣庤钘ユ績搴�

D銆佺┅(w臎n)鎱�(t脿i)琛€钘ユ績搴�

E銆佸钩鍧囪钘ユ績搴�

2銆佸柈瀹ゆā鍨嬭绠″绲﹁棩鐨勮钘ユ績搴﹁垏鏅�(sh铆)闁撶殑闂�(gu膩n)绯荤偤

A銆丆=k0(1-e-kt)/Vk

3銆佽绠″绲﹁棩涓殑F鐐�

A銆佸惛鏀剁郴鏁�(sh霉)

B銆佹秷闄ょ郴鏁�(sh霉)

C銆佸惛鏀跺崰鍔戦噺鐨勫垎?j菒n)?sh霉)鍊�

D銆佹秷闄ゅ崰鍔戦噺鐨勫垎?j菒n)?sh霉)鍊�

E銆佺敓鐗╁埄鐢ㄥ害

4銆侀潪绶�(xi脿n)鎬у嫊(d貌ng)鍔涘(xu茅)涓叐鍊�(g猫)鏈€鍩烘湰鐨勫弮鏁�(sh霉)鏄�

A銆並

B銆乂

C銆丆l

D銆並m

E銆乂m

5銆佺敓鐗╁埄鐢ㄥ害鐨勭爺绌跺寘鎷�

A銆佺敓鐗╁埄鐢ㄩ€熷害

B銆佺敓鐗╁埄鐢ㄦ檪(sh铆)闁�

C銆佺敓鐗╁埄鐢ㄧ▼搴�

D銆佺敓鐗╁埄鐢ㄩ亷(gu貌)绋�

E銆佺敓鐗╁埄鐢ㄧ祼(ji茅)鏋�

6銆佷互涓嬪爆浜庣敓鐗╃瓑鏁堟€х殑甯哥敤绲�(t菕ng)瑷�(j矛)鍒嗘瀽鏂规硶鐨勬槸

A銆佹柟宸垎鏋�

B銆侀洐鍠伌(c猫)妾㈤(y脿n)

C銆�(1-2α)缃俊鍗€(q奴)闁�

D銆佽矟钁夋柉鍒嗘瀽

E銆佺当(t菕ng)瑷�(j矛)鐭╁垎鏋�

7銆佺敤绲�(t菕ng)瑷�(j矛)鐭╂硶鍙眰鍑虹殑钘ュ嫊(d貌ng)瀛�(xu茅)鍙冩暩(sh霉)鏈�

A銆乂ss

B銆乼1/2

C銆丆l

D銆乼max

E銆�α

8銆佸奖闊跨郸钘ユ柟妗堢殑鍥犵礌鏈�

A銆佽棩鐗╃殑钘ョ悊娲绘€�

B銆佺郸钘ユ檪(sh铆)闁�

C銆佽棩鍕�(d貌ng)瀛�(xu茅)鐗规€�

D銆佹偅鑰呯殑鍊�(g猫)楂斿洜绱�

E銆佺郸钘ュ姂閲�

9銆佺郸钘ユ柟妗�?j矛ng)鈧�(g猫)楂斿寲鏂规硶鍖呮嫭

A銆佹瘮渚嬫硶

B銆佷竴榛�(di菐n)娉�

C銆佸叐榛�(di菐n)娉�

D銆侀噸寰�(f霉)涓€榛�(di菐n)娉�

E銆侀噸寰�(f霉)鍏╅粸(di菐n)娉�

10銆侀棞(gu膩n)浜庨€熺巼甯告暩(sh霉)鐨勮(shu艒)娉曟纰虹殑鏄�

A銆佷竴绱�(j铆)閫熺巼閬�(gu貌)绋嬬殑閫熷害鑸囨績搴︽垚姝ｆ瘮

B銆侀浂绱�(j铆)閫熷害閬�(gu貌)绋嬬殑閫熷害鎭掑畾

C銆侀€熺巼甯告暩(sh霉)瓒婂ぇ锛岃〃鏄庡叾楂斿収(n猫i)閬�(gu貌)绋嬮€熷害瓒婂揩

D銆侀€熺巼甯告暩(sh霉)鐨勫柈浣嶆槸鏅�(sh铆)闁撶殑鍊掓暩(sh霉)

E銆侀浂绱�(j铆)閫熺巼甯告暩(sh霉)鑸囨績搴︽湁闂�(gu膩n)绯�

绛旀閮ㄥ垎

涓€銆佹渶浣抽伕鎿囬

1銆�

銆愭纰虹瓟妗堛€� B

銆愮瓟妗堣В鏋愩€� 閬�(d谩)绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴︾殑鍒�?j菒n)?sh霉)fss=1-(1/2)n锛宯=-3.323lg(1-fss)锛宯=2→75%銆�

2銆�

銆愭纰虹瓟妗堛€� D

銆愮瓟妗堣В鏋愩€� 鏍规摎(j霉)鍏紡锛歵1/2=0.693/k瑷�(j矛)绠�锛屽叾涓璽1/2鐐鸿棩鐗╁崐琛版湡銆倀1/2=0.693/k=0.693/0.0346h-1=20h銆�

3銆�

銆愭纰虹瓟妗堛€� C

銆愮瓟妗堣В鏋愩€� 涓嶈珫浣曠ó钘ョ墿锛岄仈(d谩)绌�(w臎n)鎱�(t脿i)鐩稿悓鍒�?j菒n)?sh霉)鎵€闇€鍗婅“鏈熺殑鍊�(g猫)鏁�(sh霉)鐩稿悓锛岀稉(j墨ng)閬�(gu貌)3鍊�(g猫)鍗婅“鏈熷悗锛岃钘ユ績搴﹂仈(d谩)鍒扮┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︾殑88%銆�

4銆�

銆愭纰虹瓟妗堛€� D

銆愮瓟妗堣В鏋愩€� 鍒╃敤鍏紡锛氳“娓涢噺=1-(1/2)n鍙互瑷�(j矛)绠楀緱鍑虹瓟妗堬紝n绛変簬鍗婅“鏈熺殑鍊�(g猫)鏁�(sh霉)銆�

5銆�

銆愭纰虹瓟妗堛€� D

銆愮瓟妗堣В鏋愩€� 棣栧姂閲忕敤X0渚�(l谩i)琛ㄧず锛屾墍浠ュ湪CD涓伕鎿囷紝涓旇棩鐗╁浐瀹氬悗鏄竴鍊�(g猫)鍥哄畾鐨勫父鏁�(sh霉)锛孋涓湁璁婇噺t涓嶅皪(du矛)锛屾墍浠ユ噳(y墨ng)閬窪銆�

6銆�

銆愭纰虹瓟妗堛€� C

銆愮瓟妗堣В鏋愩€� 琛€绠″绲﹁棩妯″瀷涓�锛岄珨鍏�(n猫i)钘ョ墿璁婂寲閫熷害绛変簬鍚告敹閫熷害鑸囨秷闄ら€熷害涔嬪樊銆�

7銆�

銆愭纰虹瓟妗堛€� A

銆愮瓟妗堣В鏋愩€� 琛€钘ユ績搴︽洸绶�(xi脿n)鐢卞闋�(xi脿ng)鎸囨暩(sh霉)寮忚〃绀烘檪(sh铆)锛屽彲閲囩敤娈樻暩(sh霉)娉曟眰鍑哄悇鎸囨暩(sh霉)闋�(xi脿ng)涓殑鍙冩暩(sh霉)锛屽惛鏀堕€熺巼甯告暩(sh霉)ka鐨勮▓(j矛)绠楀嵆鍙敤娈樻暩(sh霉)娉曘€傛畼鏁�(sh霉)娉曟槸钘ュ嫊(d貌ng)瀛�(xu茅)涓妸涓€姊濇洸绶�(xi脿n)鍒嗘鍒嗚В鎴愯嫢骞叉寚鏁�(sh霉)鍑芥暩(sh霉)鐨勪竴绋父鐢ㄦ柟娉�銆�

8銆�

銆愭纰虹瓟妗堛€� B

銆愮瓟妗堣В鏋愩€� 钘ョ墿鐨則max鐢眐a銆乲姹哄畾锛岃垏鍔戦噺澶у皬鐒�(w煤)闂�(gu膩n)銆傝€孋max鑸嘪0鎴愭姣�銆�

9銆�

銆愭纰虹瓟妗堛€� E

銆愮瓟妗堣В鏋愩€� 鏈涓昏鑰冩煡闈炵窔(xi脿n)鎬у嫊(d貌ng)鍔涘(xu茅)鏂圭▼銆傞潪绶�(xi脿n)鎬у嫊(d貌ng)鍔涘(xu茅)鏂圭▼鐐猴細-dC/dt=VmC/(Km+C)

寮忎腑锛�-dC/dt鏄墿璩�(zh矛)鍦╰鏅�(sh铆)闁撶殑婵冨害涓嬮檷閫熷害锛孠m鐐虹背姘忓父鏁�(sh霉)锛孷m鐐鸿┎閬�(gu貌)绋嬬殑鐞嗚珫鏈€澶т笅闄嶉€熷害銆傚叾涓璌m鍜孷m鏄潪绶�(xi脿n)鎬у嫊(d貌ng)鍔涘(xu茅)鍙冩暩(sh霉)涓叐鍊�(g猫)鏈€閲嶈鐨勫父鏁�(sh霉)銆傛晠鏈绛旀鎳�(y墨ng)閬窫銆�

10銆�

銆愭纰虹瓟妗堛€� B

銆愮瓟妗堣В鏋愩€� 鑻ュ彈瑭﹀埗鍔戝拰鍙冩瘮鍒跺姂AUC鐨勫咕浣曞潎鍊兼瘮鐨�90%缃俊鍗€(q奴)闁撳湪80%锝�125%鑼冨湇鍏�(n猫i)锛屼笖Cmax骞句綍鍧囧€兼瘮鐨�90%缃俊鍗€(q奴)闁撳湪75%锝�133%鑼冨湇鍏�(n猫i)锛屽墖鍒ゅ畾鍙楄│鍒跺姂鑸囧弮姣斿埗鍔戠敓鐗╃瓑鏁堛€�

11銆�

銆愭纰虹瓟妗堛€� A

銆愮瓟妗堣В鏋愩€� 琛€钘ユ績搴︽硶鏄敓鐗╁埄鐢ㄥ害鐮旂┒鏈€甯哥敤鐨勬柟娉曘€�

12銆�

銆愭纰虹瓟妗堛€� C

銆愮瓟妗堣В鏋愩€� 闆堕殠鐭╀唬琛ㄨ棩鐗╃殑琛€钘ユ績搴﹂毃鏅�(sh铆)闁撶殑璁婂寲閬�(gu貌)绋嬶紝涓€闅庣煩浠ｈ〃浜嗚棩鐗╁湪楂斿収(n猫i)鐨勬化鐣欐儏娉�锛屼簩闅庣煩鍓囦唬琛ㄤ簡钘ョ墿鍦ㄩ珨鍏�(n猫i)婊暀鐨勮畩鐣扮▼搴�銆�

13銆�

銆愭纰虹瓟妗堛€� A

銆愮瓟妗堣В鏋愩€� 鍙ｆ湇鍥洪珨鍒跺姂鏅�(sh铆)锛屽湪鍚告敹閫�(j矛n)鍏ラ珨寰挵(hu谩n)鍓嶉渶瑕佸厛宕╄В鎴愰绮掞紝鍚庣稉(j墨ng)婧跺嚭锛屾垚鐐烘憾瑙ｅ湪娑查珨涓殑钘ョ墿锛屽啀琚惛鏀堕€�(j矛n)鍏ラ珨寰挵(hu谩n)銆傚洜姝�锛屽浐楂斿埗鍔戣棩鐗╁湪楂斿収(n猫i)鐨勫钩鍧囨化鐣欐檪(sh铆)闁�(MRT)鎳�(y墨ng)鍖呮嫭鍥洪珨鍒跺姂鐨勫钩鍧囧穿瑙ｆ檪(sh铆)闁�(MDIT)锛岃棩鐗╃殑骞冲潎婧跺嚭鏅�(sh铆)闁�(MDT)锛屾憾鍑鸿棩鐗╃殑骞冲潎鍚告敹鏅�(sh铆)闁�(MAT)鍜岃棩鐗╁湪楂斿収(n猫i)鐨勫钩鍧囪檿缃�(鍒嗗竷銆佷唬璎�銆佹帓娉�)鏅�(sh铆)闁�(MRTiv)銆傛墍浠ョ墖鍔戠殑MRT鏈€澶�銆�

14銆�

銆愭纰虹瓟妗堛€� C

銆愮瓟妗堣В鏋愩€� 闈滆剤娉ㄥ皠绲﹁棩锛屾敞灏勫姂閲忓嵆鐐篨锛屾湰椤孹=200mg锛孷=5L锛屽垵濮嬭钘ユ績搴﹀強闈滆剤娉ㄥ皠鐬枔鐨勮钘ユ績搴0=X/V=200mg/5L=40mg/L=40μg/ml銆侰=C0e-kt=40μg/ml×e-0.3465×2=20μg/ml銆�

15銆�

銆愭纰虹瓟妗堛€� D

銆愮瓟妗堣В鏋愩€� 姝ら杓冪啊(ji菐n)鍠�锛岀稉(j墨ng)閬�(gu貌)涓€鍊�(g猫)鍗婅“鏈熷墿浣欒棩閲忕偤1/2锛岀稉(j墨ng)閬�(gu貌)鍏╁€�(g猫)鍗婅“鏈熶箣鍚庯紝鍓╀綑钘ラ噺鐐�1/4锛屼笁鍊�(g猫)鍗婅“鏈熶箣鍚庡墿浣欒棩閲忕偤1/8銆傛墍浠ョ稉(j墨ng)閬�(gu貌)4鍊�(g猫)鍗婅“鏈熷悗鍓╀綑钘ラ噺灏辨槸1/16銆�

16銆�

銆愭纰虹瓟妗堛€� A

銆愮瓟妗堣В鏋愩€� 鍙湁A绗﹀悎閫熷害鑸囨檪(sh铆)闁撶殑闂�(gu膩n)绯汇€�

17銆�

銆愭纰虹瓟妗堛€� E

銆愮瓟妗堣В鏋愩€� 骞冲潎绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴﹀苟闈炴渶楂樺€艰垏鏈€浣庡€肩殑浠ｆ暩(sh霉)骞冲潎鍊�锛屽畠鏄噸寰�(f霉)绲﹁棩閬�(d谩)绌�(w臎n)鎱�(t脿i)鍚�锛屽湪涓€鍊�(g猫)绲﹁棩闁撻殧鏅�(sh铆)闁撳収(n猫i)琛€钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬬殑闈㈢⿳闄や互绲﹁棩闁撻殧鏅�(sh铆)闁撶殑鍟嗗€�銆傚娆￠噸寰�(f霉)绲﹁棩锛岀郸钘ユ鏁�(sh霉)鍏呭垎澶ф檪(sh铆)锛岃钘ユ績搴︿笉鍐嶅崌楂�锛岄仈(d谩)鍒扮┅(w臎n)鎱�(t脿i)姘村钩銆傞噸寰�(f霉)绲﹁棩鏅�(sh铆)锛岀暥(d膩ng)閬�(d谩)鍒扮┅(w臎n)鎱�(t脿i)钘ョ墿楂斿収(n猫i)钃勭⿳閲忎繚鎸佷竴鍊�(g猫)瀹氬€笺€�

18銆�

銆愭纰虹瓟妗堛€� E

銆愮瓟妗堣В鏋愩€� 鐢变簬V鍙奒閮芥槸鎵€绲﹁棩鐗╃殑“鐢熺悊瀛�(xu茅)”甯告暩(sh霉)锛屾晠鍙兘閫氶亷(gu貌)瑾�(di脿o)鏁寸郸钘ュ姂閲廥0鍙婄郸钘ユ檪(sh铆)闁撲笅渚�(l谩i)鐛插緱鐞嗘兂鐨勫钩鍧囩┅(w臎n)鎱�(t脿i)琛€钘ユ績搴�銆傚緸琛€钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓婄洿瑙€鐞嗚В锛屽彧鑳借獚(r猫n)鐐虹┅(w臎n)鎱�(t脿i)骞冲潎琛€钘ユ績搴︽槸浠嬩簬绌�(w臎n)鎱�(t脿i)鏈€楂樿钘ユ績搴�(Css)max鑸囩┅(w臎n)鎱�(t脿i)鏈€灏忚钘ユ績搴�(Css)min涔嬮枔鐨勪竴鍊�(g猫)琛€钘ユ績搴�锛岄€欏€�(g猫)婵冨害鐨勫眬闄愭€у湪浜庡畠鐒�(w煤)娉曟彁渚涜钘ユ績搴︾殑娉㈠嫊(d貌ng)鎬�銆�

19銆�

銆愭纰虹瓟妗堛€� B

銆愮瓟妗堣В鏋愩€� 娌荤檪钘ョ墿鐩�(ji膩n)娓�(c猫)鐨勮嚚搴婃剰缇╃啊(ji菐n)鍠绱嶅涓嬶細

(1)鎸囧皫(d菐o)鑷ㄥ簥鍚堢悊鐢ㄨ棩銆佹彁楂樻不鐧傛按骞�銆�

(2)纰哄畾鍚堝苟鐢ㄨ棩鐨勫師鍓�锛岃嚚搴婁笂鍚堝苟鐢ㄨ棩寮曡捣钘ユ簮鎬х柧鐥呮垨?q奴)械婊ゅ宫闀忓嵏闀滆啽?b脿o)閬撲笉灏�銆傞枊(k膩i)灞曚簡TDM鐮旂┒钘ョ墿鐨勭浉浜掍綔鐢紝灏�(du矛)纰哄畾鍚堝苟鐢ㄨ棩鍘熷墖鍏锋湁閲嶈鎰忕京銆�

(3)钘ョ墿閬�(gu貌)閲忎腑姣掔殑瑷烘柗锛岄枊(k膩i)灞昑DM灏�(du矛)闃叉钘ョ墿閬�(gu貌)閲忎腑姣掑拰钘ョ墿鎬ユ€ч亷(gu貌)閲忎腑姣掔殑瑷烘柗鍏锋湁閲嶈鎰忕京銆�

(4)浣滅偤閱�(y墨)鐧傚樊閷�(cu貌)鎴栦簨鏁呯殑閼掑畾渚濇摎(j霉)鍙婅⿻(p铆ng)鍍�(ji脿)鎮ｈ€呯敤钘ヤ緷寰炴€х殑鎵嬫銆�

20銆�

銆愭纰虹瓟妗堛€� D

銆愮瓟妗堣В鏋愩€� 闆欏妯″瀷鍋囪ō(sh猫)韬珨鐢卞叐閮ㄥ垎绲勬垚锛屽嵆钘ョ墿鍒嗗竷閫熺巼姣旇純澶х殑涓ぎ瀹よ垏鍒嗗竷杓冩參鐨勫懆閭婂銆備腑澶鍖呮嫭琛€娑插強琛€娴佷緵鎳�(y墨ng)鍏呮矝鐨勭祫绻斾腑蹇�銆佽倽銆佽厧銆佽偤銆佸収(n猫i)鍒嗘硨鑵哄強绱�(x矛)鑳炲娑�锛岃棩鐗╅€�(j矛n)鍏ラ珨寰挵(hu谩n)鍚庤兘寰堝揩鍦板垎甯冨湪鏁村€�(g猫)涓ぎ瀹わ紝琛€娑茶垏閫欎簺绲勭箶涓殑钘ョ墿婵冨害鍙繀閫熼仈(d谩)鍒板钩琛�銆傚懆閭婂浠ｈ〃琛€娑蹭緵鎳�(y墨ng)杓冨皯鐨勭祫绻�锛屽鑲岃倝锛岀毊鑶�锛岃剛鑲祫绻旂瓑锛岃棩鐗╃殑鍒嗗竷杓冩參銆傞洐瀹ゆā鍨嬭棩鐗╃敱涓ぎ瀹ら€�(j矛n)鍏ョ郴绲�(t菕ng)锛屽苟寰炰腑澶娑堥櫎锛屽湪涓ぎ瀹よ垏鍛ㄩ倞瀹や箣闁撹棩鐗╅€�(j矛n)琛岃憲鍙€嗘€х殑杞�(zhu菐n)閬�(y霉n)銆�

21銆�

銆愭纰虹瓟妗堛€� D

銆愮瓟妗堣В鏋愩€� 寰炶嚚搴婅搴﹁€冩叜锛屽垎甯冨绌嶅ぇ鎻愮ず鍒嗗竷寤ｆ垨鑰呯祫绻旀敐鍙栭噺澶�銆�

22銆�

銆愭纰虹瓟妗堛€� B

銆愮瓟妗堣В鏋愩€� 鐢熺墿鍗婅“鏈熻〃绀鸿棩鐗╁緸楂斿収(n猫i)娑堥櫎鐨勫揩鎱�銆�

23銆�

銆愭纰虹瓟妗堛€� A

銆愮瓟妗堣В鏋愩€� 鍠妯″瀷鏄竴绋渶绨�(ji菐n)鍠殑钘ュ嫊(d貌ng)瀛�(xu茅)妯″瀷銆傜暥(d膩ng)钘ョ墿閫�(j矛n)鍏ラ珨寰挵(hu谩n)鍚�锛岃兘杩呴€熷悜楂斿収(n猫i)鍚勭祫绻斿櫒瀹樺垎甯�锛屽苟寰堝揩鍦ㄨ娑茶垏鍚勭祫绻旇嚐鍣ㄤ箣闁撻仈(d谩)鍒板嫊(d貌ng)鎱�(t脿i)骞宠　鐨勯兘灞簬閫欑ó妯″瀷銆�

浜�銆侀厤浼嶉伕鎿囬

1銆�

銆愭纰虹瓟妗堛€� E

銆愭纰虹瓟妗堛€� D

銆愭纰虹瓟妗堛€� C

銆愭纰虹瓟妗堛€� A

銆愭纰虹瓟妗堛€� B

銆愮瓟妗堣В鏋愩€� 鏈鑰冩煡鍠妯″瀷琛€绠″绲﹁棩鐨勫叕寮忥紝娉ㄦ剰鎺屾彙銆�

2銆�

銆愭纰虹瓟妗堛€� E

銆愭纰虹瓟妗堛€� D

銆愭纰虹瓟妗堛€� C

銆愭纰虹瓟妗堛€� A

銆愭纰虹瓟妗堛€� B

銆愮瓟妗堣В鏋愩€� 姝ら鑰冨療鐨勬槸闈炵窔(xi脿n)鎬ц棩鍕�(d貌ng)瀛�(xu茅)鐨勫叕寮�锛岄€欓(l猫i)鍏紡鐨勭壒榛�(di菐n)鏄叕寮忎腑鍚湁Vm鎴朘m锛屾澶栬瑷樹綇鍗婅“鏈熴€佽〃瑙€鍒嗗竷瀹圭⿳銆佽钘ユ績搴�-鏅�(sh铆)闁撴洸绶�(xi脿n)涓嬮潰绌嶇殑琛ㄧず鏂规硶銆�

3銆�

銆愭纰虹瓟妗堛€� E

銆愭纰虹瓟妗堛€� A

銆愭纰虹瓟妗堛€� B

銆愭纰虹瓟妗堛€� D

銆愮瓟妗堣В鏋愩€� 姝ら鑰冩煡鐨勬槸钘ュ嫊(d貌ng)瀛�(xu茅)鐨勪竴鑸蹇�锛屾敞鎰忓崁(q奴)鍒ユ帉鎻°€傚柈瀹ゆā鍨嬭棩鐗╁湪楂斿収(n猫i)鍚勭祫绻斿櫒瀹樹腑杩呴€熷垎甯冨苟杩呴€熼仈(d谩)鍒板嫊(d貌ng)鎱�(t脿i)鍒嗗竷骞宠　銆傝棩鐗╅毃鑶芥眮閫�(j矛n)鍏ュ皬鑵稿悗琚皬鑵搁噸鏂板惛鏀剁殑鐝�(xi脿n)璞℃槸鑵歌倽寰挵(hu谩n)銆備富钘ュ埌閬�(d谩)楂斿惊鐠�(hu谩n)鐨勭浉灏�(du矛)鏁�(sh霉)閲忓拰鐩稿皪(du矛)閫熷害鏄敓鐗╁埄鐢ㄥ害銆傞珨鍏�(n猫i)钘ラ噺X鑸囪钘ユ績搴鐨勬瘮鍊兼槸琛ㄨ鍒嗗竷瀹圭⿳銆傝棩鐗╁湪楂斿収(n猫i)琛版笡涓€鍗婃墍鐢ㄧ殑鏅�(sh铆)闁撴槸鍗婅“鏈�銆�

4銆�

銆愭纰虹瓟妗堛€� D

銆愭纰虹瓟妗堛€� E

銆愭纰虹瓟妗堛€� A

銆愭纰虹瓟妗堛€� B

銆愭纰虹瓟妗堛€� C

銆愮瓟妗堣В鏋愩€� 鏈鑰冩煡鍚勫弮鏁�(sh霉)鐨勮〃绀烘柟娉�锛屾敞鎰忔帉鎻�銆�

5銆�

銆愭纰虹瓟妗堛€� A

銆愭纰虹瓟妗堛€� B

銆愭纰虹瓟妗堛€� C

銆愭纰虹瓟妗堛€� D

銆愭纰虹瓟妗堛€� E

銆愮瓟妗堣В鏋愩€� 鏈鑰冩煡绲�(t菕ng)瑷�(j矛)鐭╁師鐞嗕腑鍚勭ó鍚嶈鐨勭府瀵�(xi臎)锛屾敞鎰忓崁(q奴)鍒ユ帉鎻�銆�

6銆�

銆愭纰虹瓟妗堛€� A

銆愮瓟妗堣В鏋愩€� 瑭�(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“琛ㄨ鍒嗗竷瀹圭⿳”鐨勮嫳鏂囩府瀵�(xi臎)鐐篤d

銆愭纰虹瓟妗堛€� E

銆愮瓟妗堣В鏋愩€� 瑭�(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“绌�(w臎n)鎱�(t脿i)琛€钘ユ績搴�”鐨勮嫳鏂囩府瀵�(xi臎)鐐篊ss銆�

銆愭纰虹瓟妗堛€� D

銆愮瓟妗堣В鏋愩€� 瑭�(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“钘ユ檪(sh铆)鏇茬窔(xi脿n)涓嬮潰绌�”鑻辨枃鐐篴rea under the curve锛岀啊(ji菐n)绋�(ch膿ng)AUC銆�

銆愭纰虹瓟妗堛€� B

銆愮瓟妗堣В鏋愩€� 瑭�(p铆ng)鍍�(ji脿)鎸囨(bi膩o)“娓呴櫎鐜�”鐨勮嫳鏂囩偤 clear,绨�(ji菐n)瀵�(xi臎)鐐篊l銆�

7銆�

銆愭纰虹瓟妗堛€� E

銆愮瓟妗堣В鏋愩€� Cl= X0/AUC

銆愭纰虹瓟妗堛€� B

銆愮瓟妗堣В鏋愩€� t1/2=0.693/k

銆愭纰虹瓟妗堛€� C

銆愮瓟妗堣В鏋愩€� AUC=C0/k

銆愭纰虹瓟妗堛€� D

銆愮瓟妗堣В鏋愩€� V=X0/C0

銆愭纰虹瓟妗堛€� A

銆愮瓟妗堣В鏋愩€� C=C0e-kt

8銆�

銆愭纰虹瓟妗堛€� E

銆愭纰虹瓟妗堛€� D

銆愭纰虹瓟妗堛€� A

銆愭纰虹瓟妗堛€� B

銆愮瓟妗堣В鏋愩€� 姝ら鑰冩煡澶氬姂閲忕郸钘ョ殑鍏紡锛屾敞鎰忔帉鎻°€�

9銆�

銆愭纰虹瓟妗堛€� A

銆愭纰虹瓟妗堛€� C

銆愭纰虹瓟妗堛€� D

銆愭纰虹瓟妗堛€� E

銆愮瓟妗堣В鏋愩€� 鑲岄厫娓呴櫎鐜囨槸鍒ゆ柗鑵庡皬鐞�?y脿n)V閬�(gu貌)鍔熻兘鐨勬寚妯�(bi膩o)銆傝厧鍔熻兘姝ｅ父鐨勬垚骞寸敺鎬ц倢閰愭竻闄ょ巼鐐�100锝�120ml/min锛岃紩搴﹁厧鍔熻兘娓涢€€鑰呯偤50锝�80ml/min锛屼腑搴﹁厧鍔熻兘娓涢€€鑰呰倢閰愭竻闄ょ巼鍙檷鑷�10锝�50 ml/min锛屽毚(y谩n)閲嶈厧鍔熻兘娓涢€€鑰�<10 ml/min銆備竴鑸棩鐗╃殑鑵庢竻闄ょ巼鑸囬珨鍏�(n猫i)鑲岄厫娓呴櫎鐜囨垚姝ｆ瘮銆�

10銆�

銆愭纰虹瓟妗堛€� E

銆愭纰虹瓟妗堛€� D

銆愭纰虹瓟妗堛€� C

銆愭纰虹瓟妗堛€� B

銆愭纰虹瓟妗堛€� A

銆愮瓟妗堣В鏋愩€� 鏈鑰冩煡鐨勬槸鍚勫€�(g猫)妯″瀷涓嬬殑琛€钘ユ績搴﹀叕寮�锛屾敞鎰忓崁(q奴)鍒�銆�

11銆�

銆愭纰虹瓟妗堛€� B

銆愭纰虹瓟妗堛€� D

銆愭纰虹瓟妗堛€� A

銆愮瓟妗堣В鏋愩€� 灏�(du矛)浜庡叕寮忛鐩鍏堣浣忚〃绀烘柟娉�锛屽崐琛版湡鐢╰1/2琛ㄧず锛岃〃瑙€鍒嗗竷瀹圭⿳鐢╒琛ㄧず锛屾竻闄ょ巼鐢–l琛ㄧず銆�

涓夈€佸闋�(xi脿ng)閬告搰椤�

1銆�

銆愭纰虹瓟妗堛€� AD

銆愮瓟妗堣В鏋愩€� 闈滆剤婊存敞闁�(k膩i)濮嬬殑涓€娈垫檪(sh铆)闁撳収(n猫i)锛岃钘ユ績搴﹂€愭几涓婂崌锛岀劧鍚庤定杩戜簬鎭掑畾姘村钩锛屾鏅�(sh铆)鐨勮钘ユ績搴﹀€肩ū(ch膿ng)鐐虹┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︽垨鍧績搴�锛岀敤Css琛ㄧず銆�

2銆�

銆愭纰虹瓟妗堛€� CDE

銆愮瓟妗堣В鏋愩€� E閬搁爡(xi脿ng)鏄柈瀹ゆā鍨嬭绠″绲﹁棩鐨勫師濮嬪叕寮�锛岀暥(d膩ng)t鍏呭垎澶ф檪(sh铆)鍙啊(ji菐n)鍖栫偤鍏紡CD銆�

3銆�

銆愭纰虹瓟妗堛€� ACE

銆愮瓟妗堣В鏋愩€� F鐐哄惛鏀剁郴鏁�(sh霉)(0≤F≤1)锛岃〃绀哄惛鏀跺崰鍔戦噺鐨勫垎?j菒n)?sh霉)鍊硷紝鎴栫ū(ch膿ng)鍏剁偤“鐢熺墿鍒╃敤搴�”銆�

4銆�

銆愭纰虹瓟妗堛€� DE

銆愮瓟妗堣В鏋愩€� 1913骞�锛孧ichaelis-Menten鐧�(f膩)琛ㄤ簡鎻忚堪閰跺弮鑸囩殑鐗╄唱(zh矛)璁婂寲鍕�(d貌ng)鍔涘(xu茅)閬�(gu貌)绋�锛屽叾鏂圭▼寮忎腑 - dC/dt 鏄墿璩�(zh矛)鍦╰鏅�(sh铆)闁撶殑婵冨害涓嬮檷閫熷害锛孠m鐐虹背姘忓父鏁�(sh霉)锛孷m鐐鸿┎閬�(gu貌)绋嬬殑鐞嗚珫鏈€澶т笅闄嶉€熷害銆�

5銆�

銆愭纰虹瓟妗堛€� AC

銆愮瓟妗堣В鏋愩€� 鐢熺墿鍒╃敤搴﹀寘鎷叐鏂归潰鐨勫収(n猫i)瀹癸細鐢熺墿鍒╃敤閫熷害鑸囩敓鐗╁埄鐢ㄧ▼搴�銆�

6銆�

銆愭纰虹瓟妗堛€� ABCD

銆愮瓟妗堣В鏋愩€� 鐢熺墿绛夋晥鎬ц⿻(p铆ng)鍍�(ji脿)鏄皪(du矛)姹傚緱鐨勭敓鐗╁埄鐢ㄥ害鍙冩暩(sh霉)閫�(j矛n)琛岀当(t菕ng)瑷�(j矛)鍒嗘瀽锛岃钘ユ績搴︽硶鐨勮⿻(p铆ng)鍍�(ji脿)鍙冩暩(sh霉)鏄疉UC銆丆max銆乼max銆傚父鐢ㄧ殑绲�(t菕ng)瑷�(j矛)鍒嗘瀽鏂规硶鏈夋柟宸垎鏋�銆侀洐鍠伌(c猫)妾㈤(y脿n)锛�(1-2α)缃俊鍗€(q奴)闁撱€佽矟钁夋柉鍒嗘瀽绛�銆�

7銆�

銆愭纰虹瓟妗堛€� ABC

銆愮瓟妗堣В鏋愩€� 鏈涓昏鑰冩煡绲�(t菕ng)瑷�(j矛)璺濇噳(y墨ng)鐢�銆傜敤绲�(t菕ng)瑷�(j矛)璺濇硶浼扮畻钘ョ墿鍕�(d貌ng)鍔涘(xu茅)鍙冩暩(sh霉)锛屽彲浠ユ眰鍑哄崐琛版湡銆佹竻闄ょ巼銆佺┅(w臎n)鎱�(t脿i)琛ㄨ鍒嗗竷瀹圭⿳绛夛紝涓嶈兘姹傚嚭閬�(d谩)宄版檪(sh铆)闁撳拰娣烽洔鍙冩暩(sh霉)銆傛晠鏈绛旀鎳�(y墨ng)閬窤BC銆�

8銆�

銆愭纰虹瓟妗堛€� ACD

銆愮瓟妗堣В鏋愩€� 褰遍熆绲﹁棩鏂规鐨勫洜绱犳湁锛氳棩鐗╃殑钘ョ悊娲绘€�銆佽棩鍕�(d貌ng)瀛�(xu茅)鐗规€у拰鎮ｈ€呯殑鍊�(g猫)楂斿洜绱犵瓑銆傜郸钘ユ柟妗堣ō(sh猫)瑷�(j矛)鐨勭洰鐨勫氨鏄纰哄畾绲﹁棩鏅�(sh铆)闁撳拰绲﹁棩鍔戦噺銆�

9銆�

銆愭纰虹瓟妗堛€� ABD

銆愮瓟妗堣В鏋愩€� 绲﹁棩鏂规?j矛ng)鈧�(g猫)楂斿寲鏂规硶鍖呮嫭锛氭瘮渚嬫硶銆佷竴榛�(di菐n)娉曞拰閲嶅京(f霉)涓€榛�(di菐n)娉曘€�

10銆�

銆愭纰虹瓟妗堛€� ABCD

銆愮瓟妗堣В鏋愩€� 涓€浜涜棩鐗╁瓨鍦ㄤ富鍕�(d貌ng)杞�(zhu菐n)閬�(y霉n)鎴栬級楂旇綁(zhu菐n)閬�(y霉n)锛岀暥(d膩ng)钘ョ墿婵冨害澶у埌涓€瀹氱▼搴﹀悗锛岃級楂旇椋藉拰锛岃棩鐗╃殑杞�(zhu菐n)閬�(y霉n)閫熷害鑸囨績搴︾劇(w煤)闂�(gu膩n)锛岄€熷害淇濇寔鎭掑畾锛屾鏅�(sh铆)鐐洪浂绱�(j铆)閫熷害閬�(gu貌)绋嬨€�

2020鍩�(zh铆)妤�(y猫)钘ュ斧鑰冭│缍�(w菐ng)涓婂牨(b脿o)鍚嶆毇鏈枊(k膩i)濮�銆傜偤浜嗗公鍔╁ぇ瀹剁嵅鍙�2020鍩�(zh铆)妤�(y猫)钘ュ斧鑰冭│鐩搁棞(gu膩n)鏅�(sh铆)闁撶瘈(ji茅)榛�(di菐n)璩囪▕锛岀挵(hu谩n)鐞冪恫(w菐ng)鏍℃彁渚�“ 鍏嶈不(f猫i)闋�(y霉)绱勭煭淇℃彁閱�”锛屽眴鏅�(sh铆)灏囦互鐭俊褰㈠紡鎻愰啋澶у2020骞村悇鍦板崁(q奴)鍩�(zh铆)妤�(y猫)钘ュ斧鍫�(b脿o)鍚嶆檪(sh铆)闁�銆佽€冭│鏅�(sh铆)闁撶瓑閲嶈鑰冭│鏅�(sh铆)闁撹硣瑷�銆�

浠ヤ笂灏辨槸2020鍩�(zh铆)妤�(y猫)钘ュ斧妯℃摤瑭﹂锛氥€婅棩瀛�(xu茅)灏�(zhu膩n)妤�(y猫)鐭ヨ瓨(sh铆)涓€銆�绗節绔�钘ョ墿鐨勯珨鍏�(n猫i)鍕�(d貌ng)鍔涘(xu茅)閬�(gu貌)绋�鐨�鍏�(n猫i)瀹�锛�灏忕法宸插皣涓婅堪瑭﹂閫ｅ悓鍏朵粬绔犵瘈(ji茅)鐨勮│椤屽収(n猫i)瀹规暣鐞嗙偤word鏂囨獢锛岄粸(di菐n)鎿婁笅鏂规寜閳曞嵆鍙�鍏嶈不(f猫i)涓嬭級锛侀倓鏈夊煼(zh铆)妤�(y猫)钘ュ斧姝峰勾楂橀牷鑰冮粸(di菐n)銆佺湡椤岃В鏋�绛夊倷鑰冭硣鏂�锛岀瓑浣犲厤璨�(f猫i)涓嬭級瀛�(xu茅)缈�(x铆)锛�